Potency of the novel PolC DNA polymerase inhibitor CRS0540 in a disseminated Listeria monocytogenes intracellular hollow-fibre model

• Published in: Journal of antimicrobial chemotherapy Vol. 77; no. 10; pp. 2876 - 2885
• Main Authors: Patel, Swati, Chapagain, Moti, Mason, Clifford, Gingrich, Matthew, Athale, Shruti, Ribble, Wendy, Hoang, Teresa, Day, Joshua, Sun, Xicheng, Jarvis, Thale, Ochsner, Urs A, Howe, David, Gumbo, Tawanda
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 30.09.2022
• Subjects: Original Research

Abstract Background Listeriosis is an orphan disease, which is nevertheless fatal in immunocompromised people. CRS0540 is a novel PolC DNA polymerase inhibitor that has demonstrated good in vitro and in vivo activity against Listeria monocytogenes. Methods Rodent-to-human allometry projection-based...