TPPP acts downstream of RhoA-ROCK-LIMK2 to regulate astral microtubule organization and spindle orientation

• Published in: Journal of cell science Vol. 125; no. Pt 6; pp. 1579 - 1590
• Main Authors: Heng, Yi-Wen, Lim, Hong-Hwa, Mina, Theresia, Utomo, Prayudi, Zhong, Shaoping, Lim, Chwee-Teck, Koh, Cheng-Gee
• Format: Journal Article
• Language: English
• Published: England 15.03.2012
• Subjects: Actin Cytoskeleton - genetics; Actin Cytoskeleton - metabolism; Actin Cytoskeleton - physiology; HeLa Cells; Humans; Lim Kinases - genetics; Lim Kinases - physiology; Metaphase - genetics; Microtubule Proteins - genetics; Microtubule Proteins - physiology; Nerve Tissue Proteins - genetics; Nerve Tissue Proteins - physiology; rho-Associated Kinases - genetics; rho-Associated Kinases - physiology; rhoA GTP-Binding Protein - genetics; rhoA GTP-Binding Protein - physiology; Spindle Apparatus - genetics; Spindle Apparatus - physiology

The actin cytoskeleton in eukaryotic cells undergoes drastic rearrangement during mitosis. The changes to the actin cytoskeleton are most obvious in the adherent cells, where the actin stress fibres are disassembled, and the cortical actin network becomes more prominent with concomitant increase in...