Oscillatory shear stress promotes endothelial senescence and atherosclerosis via STING activation

• Published in: Biochemical and biophysical research communications Vol. 715; p. 149979
• Main Authors: Dong, Mengdie, Chen, Minghong, Zhang, Yunjia, He, Xian, Min, Jiao, Tan, Yongkang, Wei, Huiyuan, Li, Xinyu, Chen, Xiang, Zheng, Longbin, Yin, Quanwen, Li, Xuesong, Chen, Hongshan, Jiang, Hong
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 30.06.2024
• Subjects: Animals; atherogenesis; Atherosclerosis; Atherosclerosis - genetics; Atherosclerosis - metabolism; Atherosclerosis - pathology; blood flow; Cells, Cultured; Cellular Senescence - genetics; Diet, High-Fat; DNA, Mitochondrial - genetics; DNA, Mitochondrial - metabolism; Endothelial Cells - metabolism; Endothelial Cells - pathology; Endothelial senescence; Endothelium, Vascular - metabolism; Endothelium, Vascular - pathology; high fat diet; Humans; Membrane Proteins - genetics; Membrane Proteins - metabolism; Mice; Mice, Inbred C57BL; mitochondria; Mitochondria - metabolism; Mitochondria - pathology; mitochondrial DNA; Oscillatory shear stress; shear stress; STING; Stress, Mechanical; therapeutics; STING; Oscillatory shear stress; Atherosclerosis; Endothelial senescence
• ISSN: 0006-291X; 1090-2104; 1090-2104
• DOI: 10.1016/j.bbrc.2024.149979

Endothelial dysfunction is an initiating factor in atherosclerosis. Endothelial cells (ECs) are constantly subject to blood flow shear stress, and atherosclerotic plaques tend to occur in aortic bends or bifurcations impaired by low oscillatory shear stress (OSS). However, the mechanism that how OSS...