Prevalence of the partial molar phenotype in triploidy of maternal and paternal origin

• Published in: Human pathology Vol. 29; no. 5; pp. 505 - 511
• Main Authors: Redline, Raymond W, Hassold, Terry, Zaragoza, Michael V
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.05.1998; Elsevier
• Subjects: Adult; Biological and medical sciences; Diseases of mother, fetus and pregnancy; DNA, Neoplasm - analysis; Fathers; Female; gestational trophoblastic disease; Gynecology. Andrology. Obstetrics; Humans; Hydatidiform Mole - genetics; Hydatidiform Mole - pathology; Karyotyping; Male; Medical sciences; Mothers; partial mole; Phenotype; Polymerase Chain Reaction; Polyploidy; Pregnancy; Pregnancy. Fetus. Placenta; Prevalence; triploidy; trophoblast; Trophoblastic Neoplasms - genetics; Trophoblastic Neoplasms - pathology; Uterine Neoplasms - genetics; Uterine Neoplasms - pathology; GTD; H&E; gestational trophoblastic disease; partial mole; trophoblast; triploidy; PM; PCR; Human; Origin; Trophoblaste pathology; Pregnancy disorders; Hydatidiform mole; Placenta diseases; Differential diagnostic; Polymerase chain reaction; Pathology; Phenotype; Placenta; Mother; Partial; Tumor; Female; Diagnosis; Triploidy; Molecular biology; Father

Triploid partial moles are at risk for trophoblastic neoplasia, yet the prevalence, parent of origin, and evolution of the partial molar phenotype amongst all triploids remains controversial. We determined parental origin by polymerase chain reaction (PCR) analysis, stage of development by gross and...