Prevalence of the partial molar phenotype in triploidy of maternal and paternal origin
Triploid partial moles are at risk for trophoblastic neoplasia, yet the prevalence, parent of origin, and evolution of the partial molar phenotype amongst all triploids remains controversial. We determined parental origin by polymerase chain reaction (PCR) analysis, stage of development by gross and...
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Published in | Human pathology Vol. 29; no. 5; pp. 505 - 511 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
New York, NY
Elsevier Inc
01.05.1998
Elsevier |
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Abstract | Triploid partial moles are at risk for trophoblastic neoplasia, yet the prevalence, parent of origin, and evolution of the partial molar phenotype amongst all triploids remains controversial. We determined parental origin by polymerase chain reaction (PCR) analysis, stage of development by gross and histological criteria, and partial molar status according to strict diagnostic criteria for all triploids identified amongst 1,054 consecutively karyotyped spontaneous abortions. Triploidy was detected in 64 of 832 successfully karyotyped specimens. Complete data were collected in 59 cases. Diandric origin was found in 39 specimens, and 20 of these fulfilled all four criteria for partial mole (trophoblast hyperplasia, dimorphic population of large and small villi, villous hydrops greater than 0.5 mm, and irregular villous contour). We separated the 19 diandric triploids not fulfilling all criteria for partial mole into four groups: specimens of early developmental stage, which we believed represented developing (“early”) partial moles (n = 3), cases of late developmental stage, which we believed represented involuting (“ancient”) partial moles (n = 4), cases showing some but not all criteria for partial mole (n = 7), and specimens with few if any criteria suggestive of partial mole (n = 5). In triploids of digynic origin (n = 20), developmental stage was significantly lower, fetal tissue was more frequently identified, and all specimens showed well-preserved fetal red blood cells. Digynic triploids occasionally showed irregular contour, dimorphic villi, and a mild form of trophoblast hyperplasia but never showed hydropic degeneration and were never suspicious for partial mole. |
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AbstractList | Triploid partial moles are at risk for trophoblastic neoplasia, yet the prevalence, parent of origin, and evolution of the partial molar phenotype amongst all triploids remains controversial. We determined parental origin by polymerase chain reaction (PCR) analysis, stage of development by gross and histological criteria, and partial molar status according to strict diagnostic criteria for all triploids identified amongst 1,054 consecutively karyotyped spontaneous abortions. Triploidy was detected in 64 of 832 successfully karyotyped specimens. Complete data were collected in 59 cases. Diandric origin was found in 39 specimens, and 20 of these fulfilled all four criteria for partial mole (trophoblast hyperplasia, dimorphic population of large and small villi, villous hydrops greater than 0.5 mm, and irregular villous contour). We separated the 19 diandric triploids not fulfilling all criteria for partial mole into four groups: specimens of early developmental stage, which we believed represented developing ("early") partial moles (n = 3), cases of late developmental stage, which we believed represented involuting ("ancient") partial moles (n = 4), cases showing some but not all criteria for partial mole (n = 7), and specimens with few if any criteria suggestive of partial mole (n = 5). In triploids of digynic origin (n = 20), developmental stage was significantly lower, fetal tissue was more frequently identified, and all specimens showed well-preserved fetal red blood cells. Digynic triploids occasionally showed irregular contour, dimorphic villi, and a mild form of trophoblast hyperplasia but never showed hydropic degeneration and were never suspicious for partial mole. |
Author | Redline, Raymond W Zaragoza, Michael V Hassold, Terry |
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Keywords | GTD H&E gestational trophoblastic disease partial mole trophoblast triploidy PM PCR Human Origin Trophoblaste pathology Pregnancy disorders Hydatidiform mole Placenta diseases Differential diagnostic Polymerase chain reaction Pathology Phenotype Placenta Mother Partial Tumor Female Diagnosis Triploidy Molecular biology Father |
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SubjectTerms | Adult Biological and medical sciences Diseases of mother, fetus and pregnancy DNA, Neoplasm - analysis Fathers Female gestational trophoblastic disease Gynecology. Andrology. Obstetrics Humans Hydatidiform Mole - genetics Hydatidiform Mole - pathology Karyotyping Male Medical sciences Mothers partial mole Phenotype Polymerase Chain Reaction Polyploidy Pregnancy Pregnancy. Fetus. Placenta Prevalence triploidy trophoblast Trophoblastic Neoplasms - genetics Trophoblastic Neoplasms - pathology Uterine Neoplasms - genetics Uterine Neoplasms - pathology |
Title | Prevalence of the partial molar phenotype in triploidy of maternal and paternal origin |
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