Muscle-specific actin expression in chondroblastomas
Chondroblastomas are unusual cartilage benign lesions of bone that have well-characterized histological features. We reviewed and immunohistochemically examined the paraffin block material of 20 cases, and in seven tumors of this collection we found distinct cytoplasmic muscle-specific actin positiv...
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Published in | Human pathology Vol. 28; no. 3; pp. 316 - 320 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
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New York, NY
Elsevier Inc
01.03.1997
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Abstract | Chondroblastomas are unusual cartilage benign lesions of bone that have well-characterized histological features. We reviewed and immunohistochemically examined the paraffin block material of 20 cases, and in seven tumors of this collection we found distinct cytoplasmic muscle-specific actin positivity of some tumor chondroblasts and chondrocytes. Muscle-specific actin-positive cells had the histological and ultrastructural features typical of chondroblasts. Moreover, in their cytoplasm they contained bundles of microfilaments with focal densities, as is typical of myofilaments. We did not observe any basal lamina around these cells, which were surrounded by intercellular matrix of the cartilage tissue type. Therefore, we suppose that muscle-specific actin-positive cells occurring in some chondroblastomas do not represent an admixture of myofibroblasts but chondroblasts with actin expression. The unusual immunophenotype of some chondroblasts might be the result of aberrant actin expression or of the plasticity of their phenotype modulated by microenvironmental stimuli. It is a question of whether, analogously to the terminology of myofibroblasts, such cells could be designated as myochondroblasts. |
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AbstractList | Chondroblastomas are unusual cartilage benign lesions of bone that have well-characterized histological features. We reviewed and immunohistochemically examined the paraffin block material of 20 cases, and in seven tumors of this collection we found distinct cytoplasmic muscle-specific actin positivity of some tumor chondroblasts and chondrocytes. Muscle-specific actin-positive cells had the histological and ultrastructural features typical of chondroblasts. Moreover, in their cytoplasm they contained bundles of microfilaments with focal densities, as is typical of myofilaments. We did not observe any basal lamina around these cells, which were surrounded by intercellular matrix of the cartilage tissue type. Therefore, we suppose that muscle-specific actin-positive cells occurring in some chondroblastomas do not represent an admixture of myofibroblasts but chondroblasts with actin expression. The unusual immunophenotype of some chondroblasts might be the result of aberrant actin expression or of the plasticity of their phenotype modulated by microenvironmental stimuli. It is a question of whether, analogously to the terminology of myofibroblasts, such cells could be designated as myochondroblasts. |
Author | Matějovsky, Zdeněk Tomanova, Radoslava Povýšil, Ctibor |
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Cites_doi | 10.1016/S0046-8177(88)80084-4 10.1016/S0046-8177(85)80016-2 10.1016/0046-8177(93)90107-R 10.1016/0046-8177(94)90087-6 10.1002/1097-0142(196405)17:5<578::AID-CNCR2820170506>3.0.CO;2-3 10.1002/1097-0142(197203)29:3<760::AID-CNCR2820290332>3.0.CO;2-U 10.1007/BF00306024 10.1016/0046-8177(95)90004-7 10.1016/S0344-0338(79)80009-6 10.1002/1097-0142(19880215)61:4<792::AID-CNCR2820610425>3.0.CO;2-V 10.1007/BF01605779 10.1111/j.1365-2559.1990.tb01112.x 10.1007/BF01605141 10.1097/00000478-199211000-00004 10.1016/S0022-5320(73)80070-X 10.1016/S0046-8177(79)80073-8 10.1093/ajcp/88.1.1 10.2106/00004623-198567050-00009 10.1097/00000478-199312000-00001 10.1002/1097-0142(19831115)52:10<1820::AID-CNCR2820521010>3.0.CO;2-3 10.2106/00004623-198668040-00006 10.1002/1097-0142(196908)24:2<408::AID-CNCR2820240225>3.0.CO;2-3 10.1007/BF01660984 10.1016/0046-8177(89)90268-2 |
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Keywords | EMA NSE electron microscopy chondroblastoma myochondroblasts muscle actin expression Human Immunohistochemistry Pathology Chondrocyte Diseases of the osteoarticular system Actins Benign neoplasm Bone Chondroblast Chondroblastoma |
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Snippet | Chondroblastomas are unusual cartilage benign lesions of bone that have well-characterized histological features. We reviewed and immunohistochemically... |
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SubjectTerms | Actins - metabolism Biological and medical sciences Cartilage - metabolism Cartilage - pathology Cartilage - ultrastructure chondroblastoma Chondroblastoma - metabolism Chondroblastoma - pathology Chondroblastoma - ultrastructure Chondroma - metabolism Chondrosarcoma - metabolism Diseases of the osteoarticular system electron microscopy Humans Immunohistochemistry Medical sciences Microscopy, Electron muscle actin expression myochondroblasts Phosphopyruvate Hydratase - metabolism S100 Proteins - metabolism Tumors of striated muscle and skeleton Vimentin - metabolism |
Title | Muscle-specific actin expression in chondroblastomas |
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