MicroRNAs as Biomarkers for Predicting Complications following Aneurysmal Subarachnoid Hemorrhage

Aneurysmal subarachnoid hemorrhage (aSAH) is a high mortality hemorrhagic stroke that affects nearly 30,000 patients annually in the United States. Approximately 30% of aSAH patients die during initial hospitalization and those who survive often carry poor prognosis with one in five having permanent...

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Published inInternational journal of molecular sciences Vol. 22; no. 17; p. 9492
Main Authors Wang, Wang-Xia, Springer, Joe E., Hatton, Kevin W.
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.09.2021
MDPI
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Aneurysms
Biomarkers
Medical imaging
MicroRNAs
Review
Veins & arteries
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Abstract Aneurysmal subarachnoid hemorrhage (aSAH) is a high mortality hemorrhagic stroke that affects nearly 30,000 patients annually in the United States. Approximately 30% of aSAH patients die during initial hospitalization and those who survive often carry poor prognosis with one in five having permanent physical and/or cognitive disabilities. The poor outcome of aSAH can be the result of the initial catastrophic event or due to the many acute or delayed neurological complications, such as cerebral ischemia, hydrocephalus, and re-bleeding. Unfortunately, no effective biomarker exists to predict or diagnose these complications at a clinically relevant time point when neurologic injury can be effectively treated and managed. Recently, a number of studies have demonstrated that microRNAs (miRNAs) in extracellular biofluids are highly associated with aSAH and complications. Here we provide an overview of the current research on relevant human studies examining the correlation between miRNAs and aSAH complications and discuss the potential application of using miRNAs as biomarkers in aSAH management.
AbstractList Aneurysmal subarachnoid hemorrhage (aSAH) is a high mortality hemorrhagic stroke that affects nearly 30,000 patients annually in the United States. Approximately 30% of aSAH patients die during initial hospitalization and those who survive often carry poor prognosis with one in five having permanent physical and/or cognitive disabilities. The poor outcome of aSAH can be the result of the initial catastrophic event or due to the many acute or delayed neurological complications, such as cerebral ischemia, hydrocephalus, and re-bleeding. Unfortunately, no effective biomarker exists to predict or diagnose these complications at a clinically relevant time point when neurologic injury can be effectively treated and managed. Recently, a number of studies have demonstrated that microRNAs (miRNAs) in extracellular biofluids are highly associated with aSAH and complications. Here we provide an overview of the current research on relevant human studies examining the correlation between miRNAs and aSAH complications and discuss the potential application of using miRNAs as biomarkers in aSAH management.
Aneurysmal subarachnoid hemorrhage (aSAH) is a high mortality hemorrhagic stroke that affects nearly 30,000 patients annually in the United States. Approximately 30% of aSAH patients die during initial hospitalization and those who survive often carry poor prognosis with one in five having permanent physical and/or cognitive disabilities. The poor outcome of aSAH can be the result of the initial catastrophic event or due to the many acute or delayed neurological complications, such as cerebral ischemia, hydrocephalus, and re-bleeding. Unfortunately, no effective biomarker exists to predict or diagnose these complications at a clinically relevant time point when neurologic injury can be effectively treated and managed. Recently, a number of studies have demonstrated that microRNAs (miRNAs) in extracellular biofluids are highly associated with aSAH and complications. Here we provide an overview of the current research on relevant human studies examining the correlation between miRNAs and aSAH complications and discuss the potential application of using miRNAs as biomarkers in aSAH management.Aneurysmal subarachnoid hemorrhage (aSAH) is a high mortality hemorrhagic stroke that affects nearly 30,000 patients annually in the United States. Approximately 30% of aSAH patients die during initial hospitalization and those who survive often carry poor prognosis with one in five having permanent physical and/or cognitive disabilities. The poor outcome of aSAH can be the result of the initial catastrophic event or due to the many acute or delayed neurological complications, such as cerebral ischemia, hydrocephalus, and re-bleeding. Unfortunately, no effective biomarker exists to predict or diagnose these complications at a clinically relevant time point when neurologic injury can be effectively treated and managed. Recently, a number of studies have demonstrated that microRNAs (miRNAs) in extracellular biofluids are highly associated with aSAH and complications. Here we provide an overview of the current research on relevant human studies examining the correlation between miRNAs and aSAH complications and discuss the potential application of using miRNAs as biomarkers in aSAH management.
Author Springer, Joe E.
Wang, Wang-Xia
Hatton, Kevin W.
AuthorAffiliation 3 Department of Anesthesiology Critical Care Medicine, University of Kentucky, Lexington, KY 40536, USA; kevin.hatton@uky.edu
2 Spinal Cord and Brain Injury Research Center, and the Department of Neuroscience, University of Kentucky, Lexington, KY 40536, USA; jspring@uky.edu
1 Sanders-Brown Center on Aging, Spinal Cord and Brain Injury Research Center, and the Pathology & Laboratory Medicine, University of Kentucky, Lexington, KY 40536, USA
AuthorAffiliation_xml – name: 3 Department of Anesthesiology Critical Care Medicine, University of Kentucky, Lexington, KY 40536, USA; kevin.hatton@uky.edu
– name: 2 Spinal Cord and Brain Injury Research Center, and the Department of Neuroscience, University of Kentucky, Lexington, KY 40536, USA; jspring@uky.edu
– name: 1 Sanders-Brown Center on Aging, Spinal Cord and Brain Injury Research Center, and the Pathology & Laboratory Medicine, University of Kentucky, Lexington, KY 40536, USA
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Cites_doi 10.1161/JAHA.112.000745
10.1371/journal.pone.0176558
10.1161/STROKEAHA.110.589275
10.1146/annurev-immunol-020711-075013
10.1042/CS20130599
10.1186/s12864-015-1341-7
10.1016/j.jocn.2018.11.038
10.1152/physiolgenomics.00168.2010
10.1016/j.wneu.2018.04.088
10.1177/0963689718773361
10.1007/s12035-019-01789-1
10.1007/s10143-020-01427-8
10.1007/s12035-016-0316-2
10.1161/CIRCRESAHA.106.141986
10.5853/jos.2016.01368
10.1016/j.bbrc.2009.09.061
10.2353/ajpath.2010.091202
10.1016/j.mrfmmm.2011.03.004
10.1016/j.atherosclerosis.2017.03.010
10.1007/s40291-016-0221-4
10.3389/fgene.2020.563166
10.1161/01.ATV.0000033517.48444.1A
10.1111/j.1750-3639.2007.00120.x
10.1016/j.gene.2018.09.010
10.3109/1354750X.2014.881418
10.1097/ANA.0000000000000130
10.1038/nature02871
10.1371/journal.pone.0018869
10.1186/gb-2009-10-6-r64
10.1227/00006123-198701000-00004
10.1016/j.tcm.2012.05.005
10.1160/TH13-11-0905
10.3171/jns.1985.63.3.0355
10.1227/00006123-197711000-00004
10.1152/physiolgenomics.00052.2015
10.3389/fneur.2013.00065
10.1007/s12028-019-00905-2
10.1016/j.anclin.2016.04.009
10.1161/STROKEAHA.110.597005
10.1371/journal.pone.0007689
10.1186/s13054-015-1036-0
10.1186/1755-8794-5-25
10.1161/STROKEAHA.114.005851
10.1161/01.CIR.102.20.2528
10.1093/cvr/cvp425
10.1016/j.bbrc.2011.02.119
10.3171/2015.11.JNS151841
10.1158/0008-5472.CAN-04-0496
10.1007/s12975-020-00793-1
10.1146/annurev-cellbio-101512-122326
10.1016/j.expneurol.2014.12.018
10.2174/15680266113139990106
10.1227/01.NEU.0000349209.69973.88
10.1038/nm738
10.2217/bmm-2016-0232
10.1227/01.neu.0000306090.30517.ae
10.1161/STROKEAHA.117.017804
10.1002/jcb.28785
10.1186/gb-2002-3-7-research0034
10.1002/jnr.21823
10.1523/JNEUROSCI.5065-07.2008
10.1161/STROKEAHA.118.021101
10.1161/ATVBAHA.109.200873
10.1515/tnsci-2017-0010
10.1016/S0092-8674(04)00045-5
10.12659/MSM.897511
10.21203/rs.3.rs-221936/v1
10.5551/jat.51102
10.1007/s40291-020-00465-8
10.1016/j.wneu.2017.09.008
10.1227/01.NEU.0000255396.23280.31
10.1042/BSR20180646
10.1155/2013/560305
10.1161/JAHA.114.000972
10.1152/physrev.00041.2003
10.1038/s41598-018-27078-w
10.3389/fneur.2014.00134
10.1007/s00701-016-3046-3
10.3171/2015.4.JNS15428
10.1136/jnnp-2014-307711
10.3171/jns.2004.101.3.0408
10.1007/s12975-013-0316-8
10.2174/156652411794859232
10.1186/s12883-014-0188-x
10.1186/1479-5876-11-296
10.4103/1673-5374.198965
10.3171/2016.1.JNS151454
10.1042/BSR20160480
10.1186/1755-8794-6-36
10.1007/s00234-009-0575-y
10.3389/fmolb.2021.657258
10.1038/srep43633
10.1002/cncr.11409
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References Hong (ref_86) 2014; 19
Kumar (ref_19) 2016; 124
Iyer (ref_51) 2017; 261
Huang (ref_34) 2017; 8
ref_13
Supriya (ref_80) 2020; 24
Wei (ref_48) 2017; 17
Bache (ref_68) 2017; 48
Lopes (ref_63) 2018; 8
Jung (ref_87) 2013; 2013
Albinsson (ref_40) 2010; 30
Thelin (ref_90) 2017; 159
Furgeson (ref_56) 2010; 86
Amiri (ref_85) 2013; 4
Colombo (ref_95) 2014; 30
Wang (ref_26) 2015; 265
Wang (ref_25) 2008; 28
Vergouwen (ref_12) 2010; 41
Liu (ref_23) 2011; 43
Nelson (ref_24) 2008; 18
Hoshino (ref_59) 2000; 102
Xu (ref_33) 2018; 27
Jin (ref_83) 2013; 11
Kin (ref_52) 2012; 1
Khoshnam (ref_29) 2017; 19
Lantigua (ref_4) 2015; 19
ref_72
Ambros (ref_20) 2004; 431
Guo (ref_55) 2018; 42
Fisher (ref_15) 1977; 1
ref_78
Mestdagh (ref_99) 2009; 10
Kanner (ref_88) 2003; 97
Ferguson (ref_7) 2007; 60
Powers (ref_75) 2016; 48
Crowley (ref_14) 2011; 42
Sala (ref_60) 2014; 112
Proust (ref_76) 2018; 49
Milhorat (ref_9) 1987; 20
Li (ref_73) 2014; 3
Ji (ref_42) 2007; 100
Luo (ref_46) 2016; 22
Etheridge (ref_93) 2011; 717
Brathwaite (ref_6) 2014; 5
Xu (ref_54) 2018; 679
Cahill (ref_82) 2006; 26
ref_81
Seule (ref_5) 2020; 33
Shea (ref_3) 2007; 61
ref_84
Miller (ref_64) 2014; 2014
Boon (ref_41) 2011; 21
Kikkawa (ref_71) 2017; 108
Bekelis (ref_44) 2016; 125
Cordes (ref_28) 2009; 460
ref_53
Yang (ref_66) 2019; 120
Monbailliu (ref_89) 2017; 11
Gareev (ref_94) 2020; 44
Wang (ref_27) 2010; 177
Stylli (ref_79) 2017; 126
Backes (ref_92) 2016; 20
Etminan (ref_18) 2011; 31
ref_67
Owens (ref_61) 2004; 84
Koutsis (ref_22) 2013; 13
Tan (ref_36) 2011; 11
Budohoski (ref_11) 2014; 85
Chan (ref_38) 2019; 62
Andersen (ref_98) 2004; 64
Peplow (ref_35) 2017; 12
Cheng (ref_70) 2020; 40
(ref_2) 2015; 27
Sima (ref_57) 2017; 7
Dority (ref_1) 2016; 34
ref_31
ref_30
Rao (ref_32) 2012; 30
Sheng (ref_77) 2018; 116
Bartel (ref_21) 2004; 116
Heuer (ref_96) 2004; 101
Kolias (ref_8) 2009; 87
ref_39
Wang (ref_100) 2016; 54
ref_37
Bache (ref_69) 2020; 11
Boyle (ref_65) 2002; 22
Shindo (ref_58) 2002; 8
Mraz (ref_91) 2009; 390
Vandesompele (ref_97) 2002; 3
Nakaoka (ref_49) 2014; 45
Pan (ref_43) 2011; 408
Korostynski (ref_62) 2019; 57
ref_47
ref_45
Hijdra (ref_10) 1985; 63
Liao (ref_74) 2020; 27
Carrera (ref_16) 2009; 65
Dankbaar (ref_17) 2009; 51
Biros (ref_50) 2014; 126
References_xml – volume: 1
  start-page: e000745
  year: 2012
  ident: ref_52
  article-title: Tissue- and Plasma-Specific MicroRNA Signatures for Atherosclerotic Abdominal Aortic Aneurysm
  publication-title: J. Am. Heart Assoc.
  doi: 10.1161/JAHA.112.000745
– ident: ref_84
  doi: 10.1371/journal.pone.0176558
– volume: 41
  start-page: 2391
  year: 2010
  ident: ref_12
  article-title: Definition of Delayed Cerebral Ischemia after Aneurysmal Subarachnoid Hemorrhage as an Outcome Event in Clinical Trials and Observational Studies
  publication-title: Stroke
  doi: 10.1161/STROKEAHA.110.589275
– volume: 17
  start-page: 891
  year: 2017
  ident: ref_48
  article-title: Identification of key genes, transcription factors and microRNAs involved in intracranial aneurysm
  publication-title: Mol. Med. Rep.
– volume: 42
  start-page: 1637
  year: 2018
  ident: ref_55
  article-title: Dysregulation of microRNA-23b-3p contributes to the development of intracranial aneurysms by targeting phosphatase and tensin homolog
  publication-title: Int. J. Mol. Med.
– volume: 30
  start-page: 295
  year: 2012
  ident: ref_32
  article-title: microRNA Regulation of Inflammatory Responses
  publication-title: Annu. Rev. Immunol.
  doi: 10.1146/annurev-immunol-020711-075013
– volume: 126
  start-page: 795
  year: 2014
  ident: ref_50
  article-title: microRNA profiling in patients with abdominal aortic aneurysms: The significance of miR-155
  publication-title: Clin. Sci.
  doi: 10.1042/CS20130599
– ident: ref_31
  doi: 10.1186/s12864-015-1341-7
– volume: 62
  start-page: 155
  year: 2019
  ident: ref_38
  article-title: Plasma and CSF miRNA dysregulations in subarachnoid hemorrhage reveal clinical courses and underlying pathways
  publication-title: J. Clin. Neurosci.
  doi: 10.1016/j.jocn.2018.11.038
– volume: 43
  start-page: 571
  year: 2011
  ident: ref_23
  article-title: MicroRNA in central nervous system trauma and degenerative disorders
  publication-title: Physiol. Genom.
  doi: 10.1152/physiolgenomics.00168.2010
– volume: 2014
  start-page: 1
  year: 2014
  ident: ref_64
  article-title: Inflammation, Vasospasm, and Brain Injury after Subarachnoid Hemorrhage
  publication-title: Biomed. Res. Int.
– volume: 460
  start-page: 705
  year: 2009
  ident: ref_28
  article-title: miR-145 and miR-143 regulate smooth muscle cell fate and plasticity
  publication-title: Nat. Cell Biol.
– volume: 116
  start-page: e92
  year: 2018
  ident: ref_77
  article-title: Persistent High Levels of miR-502-5p Are Associated with Poor Neurologic Outcome in Patients with Aneurysmal Subarachnoid Hemorrhage
  publication-title: World Neurosurg.
  doi: 10.1016/j.wneu.2018.04.088
– volume: 27
  start-page: 1778
  year: 2018
  ident: ref_33
  article-title: The Roles of MicroRNAs in Stroke: Possible Therapeutic Targets
  publication-title: Cell Transplant.
  doi: 10.1177/0963689718773361
– volume: 57
  start-page: 988
  year: 2019
  ident: ref_62
  article-title: Inflammatory Responses Induced by the Rupture of Intracranial Aneurysms Are Modulated by miRNAs
  publication-title: Mol. Neurobiol.
  doi: 10.1007/s12035-019-01789-1
– volume: 44
  start-page: 2025
  year: 2020
  ident: ref_94
  article-title: Diagnostic and prognostic potential of circulating miRNAs for intracranial aneurysms
  publication-title: Neurosurg. Rev.
  doi: 10.1007/s10143-020-01427-8
– volume: 54
  start-page: 8191
  year: 2016
  ident: ref_100
  article-title: A Customized Quantitative PCR MicroRNA Panel Provides a Technically Robust Context for Studying Neurodegenerative Disease Biomarkers and Indicates a High Correlation between Cerebrospinal Fluid and Choroid Plexus MicroRNA Expression
  publication-title: Mol. Neurobiol.
  doi: 10.1007/s12035-016-0316-2
– volume: 31
  start-page: 1443
  year: 2011
  ident: ref_18
  article-title: Effect of pharmaceutical treatment on vasospasm, delayed cerebral ischemia, and clinical outcome in patients with aneurysmal subarachnoid hemorrhage: A systematic review and meta-analysis
  publication-title: Br. J. Pharmacol.
– volume: 100
  start-page: 1579
  year: 2007
  ident: ref_42
  article-title: MicroRNA Expression Signature and Antisense-Mediated Depletion Reveal an Essential Role of MicroRNA in Vascular Neointimal Lesion Formation
  publication-title: Circ. Res.
  doi: 10.1161/CIRCRESAHA.106.141986
– volume: 19
  start-page: 166
  year: 2017
  ident: ref_29
  article-title: Emerging Roles of microRNAs in Ischemic Stroke: As Possible Therapeutic Agents
  publication-title: J. Stroke
  doi: 10.5853/jos.2016.01368
– volume: 390
  start-page: 1
  year: 2009
  ident: ref_91
  article-title: MicroRNA isolation and stability in stored RNA samples
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2009.09.061
– volume: 177
  start-page: 334
  year: 2010
  ident: ref_27
  article-title: miR-107 Regulates Granulin/Progranulin with Implications for Traumatic Brain Injury and Neurodegenerative Disease
  publication-title: Am. J. Pathol.
  doi: 10.2353/ajpath.2010.091202
– volume: 717
  start-page: 85
  year: 2011
  ident: ref_93
  article-title: Extracellular microRNA: A new source of biomarkers
  publication-title: Mutat. Res. Mol. Mech. Mutagen.
  doi: 10.1016/j.mrfmmm.2011.03.004
– volume: 261
  start-page: 78
  year: 2017
  ident: ref_51
  article-title: A systematic review investigating the association of microRNAs with human abdominal aortic aneurysms
  publication-title: Atherosclerosis
  doi: 10.1016/j.atherosclerosis.2017.03.010
– volume: 20
  start-page: 509
  year: 2016
  ident: ref_92
  article-title: Specific miRNA Disease Biomarkers in Blood, Serum and Plasma: Challenges and Prospects
  publication-title: Mol. Diagn. Ther.
  doi: 10.1007/s40291-016-0221-4
– ident: ref_67
  doi: 10.3389/fgene.2020.563166
– volume: 40
  start-page: 775
  year: 2020
  ident: ref_70
  article-title: MicroRNA and their target mRNAs change expression in whole blood of patients after intracerebral hemorrhage
  publication-title: Br. J. Pharmacol.
– volume: 22
  start-page: 1624
  year: 2002
  ident: ref_65
  article-title: Human Macrophage-Induced Vascular Smooth Muscle Cell Apoptosis Requires NO Enhancement of Fas/Fas-L Interactions
  publication-title: Arter. Thromb. Vasc. Biol.
  doi: 10.1161/01.ATV.0000033517.48444.1A
– volume: 18
  start-page: 130
  year: 2008
  ident: ref_24
  article-title: MicroRNAs (miRNAs) in Neurodegenerative Diseases
  publication-title: Brain Pathol.
  doi: 10.1111/j.1750-3639.2007.00120.x
– volume: 679
  start-page: 266
  year: 2018
  ident: ref_54
  article-title: The miR-143/145 cluster reverses the regulation effect of KLF5 in smooth muscle cells with proliferation and contractility in intracranial aneurysm
  publication-title: Gene
  doi: 10.1016/j.gene.2018.09.010
– volume: 19
  start-page: 95
  year: 2014
  ident: ref_86
  article-title: Biomarkers as outcome predictors in subarachnoid hemorrhage—A systematic review
  publication-title: Biomarkers
  doi: 10.3109/1354750X.2014.881418
– volume: 27
  start-page: 222
  year: 2015
  ident: ref_2
  article-title: Aneurysmal Subarachnoid Hemorrhage
  publication-title: J. Neurosurg. Anesthesiol.
  doi: 10.1097/ANA.0000000000000130
– volume: 431
  start-page: 350
  year: 2004
  ident: ref_20
  article-title: The functions of animal microRNAs
  publication-title: Nature
  doi: 10.1038/nature02871
– ident: ref_39
  doi: 10.1371/journal.pone.0018869
– volume: 10
  start-page: R64
  year: 2009
  ident: ref_99
  article-title: A novel and universal method for microRNA RT-qPCR data normalization
  publication-title: Genome Biol.
  doi: 10.1186/gb-2009-10-6-r64
– volume: 20
  start-page: 15
  year: 1987
  ident: ref_9
  article-title: Acute Hydrocephalus after Aneurysmal Subarachnoid Hemorrhage
  publication-title: Neurosurgery
  doi: 10.1227/00006123-198701000-00004
– volume: 21
  start-page: 172
  year: 2011
  ident: ref_41
  article-title: MicroRNAs and Aneurysm Formation
  publication-title: Trends Cardiovasc. Med.
  doi: 10.1016/j.tcm.2012.05.005
– volume: 112
  start-page: 796
  year: 2014
  ident: ref_60
  article-title: MiR-143/145 deficiency attenuates the progression of atherosclerosis in Ldlr/mice
  publication-title: Thromb. Haemost.
  doi: 10.1160/TH13-11-0905
– volume: 63
  start-page: 355
  year: 1985
  ident: ref_10
  article-title: Acute hydrocephalus after aneurysmal subarachnoid hemorrhage
  publication-title: J. Neurosurg.
  doi: 10.3171/jns.1985.63.3.0355
– volume: 1
  start-page: 245
  year: 1977
  ident: ref_15
  article-title: Cerebral Vasospasm with Ruptured Saccular Aneurysm—The Clinical Manifestations
  publication-title: Neurosurgery
  doi: 10.1227/00006123-197711000-00004
– volume: 48
  start-page: 361
  year: 2016
  ident: ref_75
  article-title: Human cerebrospinal fluid microRNA: Temporal changes following subarachnoid hemorrhage
  publication-title: Physiol. Genom.
  doi: 10.1152/physiolgenomics.00052.2015
– volume: 4
  start-page: 65
  year: 2013
  ident: ref_85
  article-title: Can S100B Predict Cerebral Vasospasms in Patients Suffering from Subarachnoid Hemorrhage?
  publication-title: Front. Neurol.
  doi: 10.3389/fneur.2013.00065
– volume: 33
  start-page: 49
  year: 2020
  ident: ref_5
  article-title: Outcome, Return to Work and Health-Related Costs after Aneurysmal Subarachnoid Hemorrhage
  publication-title: Neurocrit. Care
  doi: 10.1007/s12028-019-00905-2
– volume: 34
  start-page: 577
  year: 2016
  ident: ref_1
  article-title: Subarachnoid Hemorrhage
  publication-title: Anesthesiol. Clin.
  doi: 10.1016/j.anclin.2016.04.009
– volume: 42
  start-page: 919
  year: 2011
  ident: ref_14
  article-title: Angiographic Vasospasm Is Strongly Correlated with Cerebral Infarction after Subarachnoid Hemorrhage
  publication-title: Stroke
  doi: 10.1161/STROKEAHA.110.597005
– ident: ref_37
  doi: 10.1371/journal.pone.0007689
– volume: 19
  start-page: 1
  year: 2015
  ident: ref_4
  article-title: Subarachnoid hemorrhage: Who dies, and why?
  publication-title: Crit. Care
  doi: 10.1186/s13054-015-1036-0
– ident: ref_53
  doi: 10.1186/1755-8794-5-25
– volume: 45
  start-page: 2239
  year: 2014
  ident: ref_49
  article-title: Gene Expression Profiling Reveals Distinct Molecular Signatures Associated with the Rupture of Intracranial Aneurysm
  publication-title: Stroke
  doi: 10.1161/STROKEAHA.114.005851
– volume: 102
  start-page: 2528
  year: 2000
  ident: ref_59
  article-title: Regulated Expression of the BTEB2 Transcription Factor in Vascular Smooth Muscle Cells
  publication-title: Circulation
  doi: 10.1161/01.CIR.102.20.2528
– volume: 86
  start-page: 274
  year: 2010
  ident: ref_56
  article-title: Inactivation of the tumour suppressor, PTEN, in smooth muscle promotes a pro-inflammatory phenotype and enhances neointima formation
  publication-title: Cardiovasc. Res.
  doi: 10.1093/cvr/cvp425
– volume: 408
  start-page: 369
  year: 2011
  ident: ref_43
  article-title: Conditional deletion of Dicer in vascular smooth muscle cells leads to the developmental delay and embryonic mortality
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2011.02.119
– volume: 125
  start-page: 1390
  year: 2016
  ident: ref_44
  article-title: MicroRNA and gene expression changes in unruptured human cerebral aneurysms
  publication-title: J. Neurosurg.
  doi: 10.3171/2015.11.JNS151841
– volume: 64
  start-page: 5245
  year: 2004
  ident: ref_98
  article-title: Normalization of Real-Time Quantitative Reverse Transcription-PCR Data: A Model-Based Variance Estimation Approach to Identify Genes Suited for Normalization, Applied to Bladder and Colon Cancer Data Sets
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-04-0496
– volume: 11
  start-page: 1243
  year: 2020
  ident: ref_69
  article-title: Elevated miR-9 in Cerebrospinal Fluid Is Associated with Poor Functional Outcome after Subarachnoid Hemorrhage
  publication-title: Transl. Stroke Res.
  doi: 10.1007/s12975-020-00793-1
– volume: 30
  start-page: 255
  year: 2014
  ident: ref_95
  article-title: Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles
  publication-title: Annu. Rev. Cell Dev. Biol.
  doi: 10.1146/annurev-cellbio-101512-122326
– volume: 265
  start-page: 84
  year: 2015
  ident: ref_26
  article-title: Mitochondria-associated microRNAs in rat hippocampus following traumatic brain injury
  publication-title: Exp. Neurol.
  doi: 10.1016/j.expneurol.2014.12.018
– volume: 13
  start-page: 1573
  year: 2013
  ident: ref_22
  article-title: The emerging role of microRNA in stroke
  publication-title: Curr. Top. Med. Chem.
  doi: 10.2174/15680266113139990106
– volume: 65
  start-page: 316
  year: 2009
  ident: ref_16
  article-title: Transcranial doppler for predicting delayed cerebral ischemia after subarachnoid hemorrhage
  publication-title: Neurosurgery
  doi: 10.1227/01.NEU.0000349209.69973.88
– volume: 8
  start-page: 856
  year: 2002
  ident: ref_58
  article-title: Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling
  publication-title: Nat. Med.
  doi: 10.1038/nm738
– volume: 11
  start-page: 503
  year: 2017
  ident: ref_89
  article-title: Blood protein biomarkers as diagnostic tool for ischemic stroke: A systematic review
  publication-title: Biomark. Med.
  doi: 10.2217/bmm-2016-0232
– volume: 61
  start-page: 1131
  year: 2007
  ident: ref_3
  article-title: Characteristics of nontraumatic subarachnoid hemorrhage in the United States in 2003
  publication-title: Neurosurgery
  doi: 10.1227/01.neu.0000306090.30517.ae
– volume: 48
  start-page: 2391
  year: 2017
  ident: ref_68
  article-title: MicroRNA Changes in Cerebrospinal Fluid after Subarachnoid Hemorrhage
  publication-title: Stroke
  doi: 10.1161/STROKEAHA.117.017804
– volume: 120
  start-page: 18618
  year: 2019
  ident: ref_66
  article-title: A functional polymorphism in the promoter region of miR-155 predicts the risk of intracranial hemorrhage caused by rupture intracranial aneurysm
  publication-title: J. Cell. Biochem.
  doi: 10.1002/jcb.28785
– volume: 3
  start-page: 0034.1
  year: 2002
  ident: ref_97
  article-title: Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes
  publication-title: Genome Biol.
  doi: 10.1186/gb-2002-3-7-research0034
– volume: 87
  start-page: 1
  year: 2009
  ident: ref_8
  article-title: Pathogenesis of cerebral vasospasm following aneurysmal subarachnoid hemorrhage: Putative mechanisms and novel approaches
  publication-title: J. Neurosci. Res.
  doi: 10.1002/jnr.21823
– volume: 28
  start-page: 1213
  year: 2008
  ident: ref_25
  article-title: The Expression of MicroRNA miR-107 Decreases Early in Alzheimer’s Disease and May Accelerate Disease Progression through Regulation of -Site Amyloid Precursor Protein-Cleaving Enzyme 1
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.5065-07.2008
– volume: 49
  start-page: 2220
  year: 2018
  ident: ref_76
  article-title: Whole-Blood miRNA Sequencing Profiling for Vasospasm in Patients with Aneurysmal Subarachnoid Hemorrhage
  publication-title: Stroke
  doi: 10.1161/STROKEAHA.118.021101
– volume: 30
  start-page: 1118
  year: 2010
  ident: ref_40
  article-title: MicroRNAs Are Necessary for Vascular Smooth Muscle Growth, Differentiation, and Function
  publication-title: Arter. Thromb. Vasc. Biol.
  doi: 10.1161/ATVBAHA.109.200873
– volume: 8
  start-page: 54
  year: 2017
  ident: ref_34
  article-title: Toward understanding non-coding RNA roles in intracranial aneurysms and subarachnoid hemorrhage
  publication-title: Transl. Neurosci.
  doi: 10.1515/tnsci-2017-0010
– volume: 116
  start-page: 281
  year: 2004
  ident: ref_21
  article-title: MicroRNAs: Genomics, Biogenesis, Mechanism, and Function
  publication-title: Cell
  doi: 10.1016/S0092-8674(04)00045-5
– volume: 22
  start-page: 4247
  year: 2016
  ident: ref_46
  article-title: Aberrant Expression of microRNA-9 Contributes to Development of Intracranial Aneurysm by Suppressing Proliferation and Reducing Contractility of Smooth Muscle Cells
  publication-title: Med. Sci. Monit.
  doi: 10.12659/MSM.897511
– ident: ref_47
  doi: 10.21203/rs.3.rs-221936/v1
– volume: 27
  start-page: 545
  year: 2020
  ident: ref_74
  article-title: Exosome-Derived MiRNAs as Biomarkers of the Development and Progression of Intracranial Aneurysms
  publication-title: J. Atheroscler. Thromb.
  doi: 10.5551/jat.51102
– volume: 26
  start-page: 1341
  year: 2006
  ident: ref_82
  article-title: Mechanisms of Early Brain Injury after Subarachnoid Hemorrhage
  publication-title: Br. J. Pharmacol.
– volume: 24
  start-page: 351
  year: 2020
  ident: ref_80
  article-title: Circulating MicroRNAs as Potential Molecular Biomarkers for Intracranial Aneurysmal Rupture
  publication-title: Mol. Diagn. Ther.
  doi: 10.1007/s40291-020-00465-8
– volume: 108
  start-page: 909
  year: 2017
  ident: ref_71
  article-title: Altered Expression of MicroRNA-15a and Kruppel-Like Factor 4 in Cerebrospinal Fluid and Plasma after Aneurysmal Subarachnoid Hemorrhage
  publication-title: World Neurosurg.
  doi: 10.1016/j.wneu.2017.09.008
– volume: 60
  start-page: 658
  year: 2007
  ident: ref_7
  article-title: Predictors of cerebral infarction in patients with aneurysmal subarachnoid hemorrhage
  publication-title: Neurosurgery
  doi: 10.1227/01.NEU.0000255396.23280.31
– ident: ref_78
  doi: 10.1042/BSR20180646
– volume: 2013
  start-page: 1
  year: 2013
  ident: ref_87
  article-title: CSF and Serum Biomarkers Focusing on Cerebral Vasospasm and Ischemia after Subarachnoid Hemorrhage
  publication-title: Stroke Res. Treat.
  doi: 10.1155/2013/560305
– volume: 3
  start-page: e000972
  year: 2014
  ident: ref_73
  article-title: Circulating microRNAs Serve as Novel Biological Markers for Intracranial Aneurysms
  publication-title: J. Am. Heart Assoc.
  doi: 10.1161/JAHA.114.000972
– volume: 84
  start-page: 767
  year: 2004
  ident: ref_61
  article-title: Molecular Regulation of Vascular Smooth Muscle Cell Differentiation in Development and Disease
  publication-title: Physiol. Rev.
  doi: 10.1152/physrev.00041.2003
– volume: 8
  start-page: 8786
  year: 2018
  ident: ref_63
  article-title: Global miRNA expression profile reveals novel molecular players in aneurysmal subarachnoid haemorrhage
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-018-27078-w
– ident: ref_13
  doi: 10.3389/fneur.2014.00134
– volume: 159
  start-page: 209
  year: 2017
  ident: ref_90
  article-title: A review of the clinical utility of serum S100B protein levels in the assessment of traumatic brain injury
  publication-title: Acta Neurochir.
  doi: 10.1007/s00701-016-3046-3
– volume: 124
  start-page: 1257
  year: 2016
  ident: ref_19
  article-title: Vasospasm on transcranial Doppler is predictive of delayed cerebral ischemia in aneurysmal subarachnoid hemorrhage: A systematic review and meta-analysis
  publication-title: J. Neurosurg.
  doi: 10.3171/2015.4.JNS15428
– volume: 85
  start-page: 1343
  year: 2014
  ident: ref_11
  article-title: The pathophysiology and treatment of delayed cerebral ischaemia following subarachnoid haemorrhage
  publication-title: J. Neurol. Neurosurg. Psychiatry
  doi: 10.1136/jnnp-2014-307711
– volume: 101
  start-page: 408
  year: 2004
  ident: ref_96
  article-title: Relationship between intracranial pressure and other clinical variables in patients with aneurysmal subarachnoid hemorrhage
  publication-title: J. Neurosurg.
  doi: 10.3171/jns.2004.101.3.0408
– volume: 5
  start-page: 207
  year: 2014
  ident: ref_6
  article-title: Current Management of Delayed Cerebral Ischemia: Update from Results of Recent Clinical Trials
  publication-title: Transl. Stroke Res.
  doi: 10.1007/s12975-013-0316-8
– volume: 11
  start-page: 76
  year: 2011
  ident: ref_36
  article-title: Micrornas in stroke pathogenesis
  publication-title: Curr. Mol. Med.
  doi: 10.2174/156652411794859232
– ident: ref_30
  doi: 10.1186/s12883-014-0188-x
– volume: 11
  start-page: 296
  year: 2013
  ident: ref_83
  article-title: Circulating microRNA: A novel potential biomarker for early diagnosis of Intracranial Aneurysm Rupture a case control study
  publication-title: J. Transl. Med.
  doi: 10.1186/1479-5876-11-296
– volume: 12
  start-page: 13
  year: 2017
  ident: ref_35
  article-title: Blood microRNAs as potential diagnostic markers for hemorrhagic stroke
  publication-title: Neural Regen. Res.
  doi: 10.4103/1673-5374.198965
– volume: 126
  start-page: 1131
  year: 2017
  ident: ref_79
  article-title: miRNA expression profiling of cerebrospinal fluid in patients with aneurysmal subarachnoid hemorrhage
  publication-title: J. Neurosurg.
  doi: 10.3171/2016.1.JNS151454
– ident: ref_72
  doi: 10.1042/BSR20160480
– ident: ref_45
  doi: 10.1186/1755-8794-6-36
– volume: 51
  start-page: 813
  year: 2009
  ident: ref_17
  article-title: Relationship between vasospasm, cerebral perfusion, and delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage
  publication-title: Neuroradiology
  doi: 10.1007/s00234-009-0575-y
– ident: ref_81
  doi: 10.3389/fmolb.2021.657258
– volume: 7
  start-page: 43633
  year: 2017
  ident: ref_57
  article-title: Association between functional polymorphisms in the promoter of the miR-143/145 cluster and risk of intracranial aneurysm
  publication-title: Sci. Rep.
  doi: 10.1038/srep43633
– volume: 97
  start-page: 2806
  year: 2003
  ident: ref_88
  article-title: Serum S100?
  publication-title: Cancer
  doi: 10.1002/cncr.11409
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Snippet Aneurysmal subarachnoid hemorrhage (aSAH) is a high mortality hemorrhagic stroke that affects nearly 30,000 patients annually in the United States....
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SubjectTerms Aneurysms
Biomarkers
Medical imaging
MicroRNAs
Review
Veins & arteries
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Title MicroRNAs as Biomarkers for Predicting Complications following Aneurysmal Subarachnoid Hemorrhage
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