Guardian of genome on the tract: Wild type p53-mdm2 complex inhibition in healing the breast cancer

• Published in: Gene Vol. 786; p. 145616
• Main Authors: S.K., Janani, S.P., Dhanabal, R., Sureshkumar, Sai Surya, Nikitha Upadhyayula, Chenmala, Karthika
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 20.06.2021
• Subjects: Anti-angiogenic activity; Anti-metastatic activity; Apoptosis; Breast cancer; breast neoplasms; Breast Neoplasms - genetics; Breast Neoplasms - metabolism; cell cycle checkpoints; Disease Progression; evolution; Female; Humans; ligases; Mdm2; mutation; neoplasm progression; P53; Proteasome Endopeptidase Complex - metabolism; Proteolysis; Proto-Oncogene Proteins c-mdm2 - metabolism; tumor suppressor genes; Tumor Suppressor Protein p53 - genetics; Tumor Suppressor Protein p53 - metabolism; World Health Organization; RNF31; PCNA; COX-2; TRADD; Anti-metastatic activity; PARP; FGF-BP; HAUSP; RNF2; BAI-1; Rb; XEDAR; L26; TSP-1; TNP; W23; FADD; AIF; MOMP; Anti-angiogenic activity; TRAIL; GADD 45; CDKN2A; VEGF; Breast cancer; ChK2; ER; EMT; ECM; F19; P53; DCFH-DA; FGF-2; FAK; DNA; MDM2; BAX; ATM; SIK1; u-PA; TP53; ATR; EPHA2; Apoptosis; Mdm2

•Breast cancer has ruined women’s life. Since, it involves complex pathways.•P53 “Guardian of genome” plays a magnificent role in inhibiting cancer growth.•Key roles of p53: apoptosis, anti-angiogenesis, anti-metastatic, cell cycle arrest.•Directly/indirectly genes and proteins are targeted by p53 i...