Lamotrigine inhibits monoamine uptake in vitro and modulates 5-hydroxytryptamine uptake in rats

• Published in: European journal of pharmacology Vol. 358; no. 1; pp. 19 - 24
• Main Authors: Southam, Eric, Kirkby, Debbie, Higgins, Guy A., Hagan, Russell M.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 25.09.1998; Elsevier
• Subjects: 5-HT (hydroxytryptamine, serotonin) uptake; Acetates - pharmacology; Amines; Animals; Anticonvulsant; Anticonvulsants - pharmacology; Biogenic Amines - antagonists & inhibitors; Biogenic Amines - pharmacokinetics; Biological and medical sciences; Bipolar disorder; Blood Platelets - drug effects; Blood Platelets - metabolism; Brain - drug effects; Brain - metabolism; Carbamazepine - pharmacology; Cyclohexanecarboxylic Acids; Dopamine - pharmacokinetics; Dopamine Uptake Inhibitors - pharmacology; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles - pharmacology; Lamotrigine; Lithium - pharmacology; Male; Medical sciences; Neuropharmacology; Norepinephrine - antagonists & inhibitors; Norepinephrine - pharmacokinetics; p-Chloroamphetamine - pharmacology; Pharmacology. Drug treatments; Phenytoin - pharmacology; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease); Psychology. Psychoanalysis. Psychiatry; Psychopharmacology; Rats; Serotonin - pharmacokinetics; Serotonin Agents - pharmacology; Serotonin Syndrome - prevention & control; Serotonin Uptake Inhibitors - pharmacology; Synaptosomes - drug effects; Synaptosomes - metabolism; Tetrodotoxin - pharmacology; Triazines - pharmacology; Valproic Acid - pharmacology; Zonisamide; Bipolar disorder; Anticonvulsant; Lamotrigine; 5-HT (hydroxytryptamine, serotonin) uptake; Human; Intraperitoneal administration; Rat; Serotonin; Psychotropic; Rodentia; Central nervous system; Reuptake inhibitor; In vitro; Uptake; In vivo; Vertebrata; Synaptosome; Platelet; Mammalia; Mood stabilizer; Animal; Mechanism of action; Brain (vertebrata)

Lamotrigine is a novel anticonvulsant drug which also stabilises mood in bipolar illness via an unknown mechanism. We report the concentration-dependent inhibition of 5-hydroxytryptamine (5-HT) uptake in both human platelets and rat brain synaptosomes (IC 50s were 240 and 474 μM, respectively) by la...