Muscarinic regulation of somatostatin release from primary cultures of human antral epithelial cells

• Published in: Pharmacology Vol. 44; no. 1; p. 33
• Main Authors: Buchan, A M, MacLeod, M D, Meloche, R M, Kwok, Y N
• Format: Journal Article
• Language: English
• Published: Switzerland 1992
• Subjects: Adult; Carbachol - pharmacology; Cells, Cultured; Epithelium - drug effects; Female; Humans; Male; Methacholine Chloride - antagonists & inhibitors; Methacholine Chloride - pharmacology; Parasympatholytics - pharmacology; Piperidines - pharmacology; Pyloric Antrum - cytology; Pyloric Antrum - drug effects; Radioimmunoassay; Receptors, Muscarinic - metabolism; Somatostatin - metabolism

A newly developed, primary culture of human antral epithelial cells has been utilized to examine the effect of parasympathomimetics on somatostatin release. The cholinergic agonists, carbachol and methacholine, stimulated somatostatin secretion in a concentration-dependent manner. Maximal release in...