Multifunctional metal-coordinated Co-assembled carrier-free nanoplatform based on dual-drugs for ferroptosis-mediated cocktail therapy of hepatocellular carcinoma growth and metastasis

• Published in: Journal of colloid and interface science Vol. 660; pp. 257 - 276
• Main Authors: Zhao, Rui-Rui, Wu, Ju-Hong, Tong, Ling-Wu, Li, Jin-Yu, Lu, Yu-sheng, Shao, Jing-Wei
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.04.2024
• Subjects: antiporters; biocompatibility; Chemodynamical therapy; cystine; cytotoxicity; drugs; epithelial cell adhesion molecule; Ferroptosis; glutamic acid; glutathione; hepatoma; hydrogen peroxide; hydroxyl radicals; immune response; Immunotherapy; Metal-coordinated nanoplatform; metastasis; oligonucleotides; phospholipid-hydroperoxide glutathione peroxidase; Synergistic chemotherapy; T-lymphocytes; ursolic acid; VEGFR2; System Xc; CPP; EpCAM; CRT; SRF; Ferroptosis; LPO; ICAM-1; HMGB1; Metal-coordinated nanoplatform; UA; DAMPs; MTX; CDT; Immunotherapy; PD-L1; GSH; GPX4; HCC; ICD; ICG; TME; TA; Chemodynamical therapy; Synergistic chemotherapy; LMWP; ATP

Herein, we designed a metal-coordinated carrier-free nanodrug (USFe3+LA NPs) with near sphere shape by co-assembling of UA, SRF, Fe3+, low molecular weight protamine (LMWP), and epithelial cell adhesion molecule (EpCAM) aptamer via a facile self-assembly method to improve the efficacy of chemotherap...