Molecular mechanisms of synergistic induction of apoptosis by the combination therapy with hyperthermia and cisplatin in prostate cancer cells

• Published in: Biochemical and biophysical research communications Vol. 479; no. 2; pp. 159 - 165
• Main Authors: Zhang, Jian-fu, Yan, Xiang-ming, Lan, Bin, Lei, Yin-rui, Li, Xiao-hu, Gao, Shuai, Guo, Yi-feng, Guo, Fang
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 14.10.2016
• Subjects: Animals; Antineoplastic Agents - pharmacology; Apoptosis; Apoptosis - drug effects; Apoptosis Regulatory Proteins - metabolism; Blotting, Western; Caspase 3 - metabolism; caspase-3; Cell Line, Tumor; Cell Proliferation - drug effects; Cell Survival - drug effects; cell viability; Cisplatin; Cisplatin - pharmacology; Combination therapy; disease course; dose response; Dose-Response Relationship, Drug; drug therapy; fever; Hot Temperature; Humans; Hyperthermia; Inhibitor of Apoptosis Proteins - metabolism; Male; males; mortality; neoplasm cells; Poly (ADP-Ribose) Polymerase-1 - metabolism; Prostate cancer; prostatic neoplasms; Prostatic Neoplasms - metabolism; Prostatic Neoplasms - pathology; proteins; Proto-Oncogene Proteins c-bcl-2 - metabolism; signal transduction; Signal Transduction - drug effects; synergism; Time Factors; United States; Western blotting; United States; Combination therapy; Hyperthermia; Prostate cancer; Cisplatin; Apoptosis

Prostate Cancer has become the second leading cause of male cancer-related incidence and mortality in United States. Hyperthermia (HT) is known to serve as a powerful tool in treatment of prostate cancer in clinical. The combination treatment with HT and cisplatin has a synergistic effect to inhibit...