Group II and III metabotropic glutamate receptors modulate paired pulse depression in the rat dentate gyrus in vitro

• Published in: European journal of pharmacology Vol. 340; no. 1; pp. 35 - 44
• Main Authors: O'Leary, Deirdre M, Cassidy, Eugene M, O'Connor, John J
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 04.12.1997; Elsevier
• Subjects: 1 S,3 R-ACPD (1 S,3 R-1-aminocyclopentate-1,3-dicarboxylic acid); Amino Acids, Dicarboxylic - pharmacology; Aminoacid receptors (glycine, glutamate, gaba); Aminobutyrates - pharmacology; Animals; Benzoates - pharmacology; Biological and medical sciences; Cell receptors; Cell structures and functions; Central nervous system; Central neurotransmission. Neuromudulation. Pathways and receptors; Cycloleucine - analogs & derivatives; Cycloleucine - pharmacology; Cyclopropanes - pharmacology; DCG-IV ((2 S,1′ R,2′ R,3′ R)-2-2′,3′-dicarboxy cyclopropylglycine); Dentate Gyrus - drug effects; Dentate Gyrus - metabolism; Evoked Potentials, Somatosensory - drug effects; Excitatory Amino Acid Agonists - pharmacology; Excitatory Amino Acid Antagonists - pharmacology; Excitatory Postsynaptic Potentials - drug effects; Fundamental and applied biological sciences. Psychology; Glycine - analogs & derivatives; Glycine - pharmacology; Hippocampal slice; In Vitro Techniques; l-AP4 ( l-2-amino-4-phosphonobutyric acid); MCPG ( α-methyl carboxy–phenylglycine); mGlu receptor; Molecular and cellular biology; Neuroprotective Agents - pharmacology; Paired pulse depression; Rats; Receptors, Metabotropic Glutamate - agonists; Receptors, Metabotropic Glutamate - antagonists & inhibitors; Resorcinols - pharmacology; Vertebrates: nervous system and sense organs; α-Methyl- l-AP4 ( α-methyl- l-amino-4-phosphonobutyric acid); 1 S,3 R-ACPD (1 S,3 R-1-aminocyclopentate-1,3-dicarboxylic acid); l-AP4 ( l-2-amino-4-phosphonobutyric acid); DCG-IV ((2 S,1′ R,2′ R,3′ R)-2-2′,3′-dicarboxy cyclopropylglycine); Hippocampal slice; α-Methyl- l-AP4 ( α-methyl- l-amino-4-phosphonobutyric acid); Paired pulse depression; mGlu receptor; MCPG ( α-methyl carboxy–phenylglycine); Rat; Depressions; Rodentia; Central nervous system; Electrophysiology; Glutamate receptor; In vitro; Neuromodulation; Mechanism; Vertebrata; Dentate gyrus; Regulation(control); Mammalia; Metabotropic receptor; Paired stimulation; Synaptic transmission; Animal; Synaptic plasticity; Subtype; Brain (vertebrata)

We have investigated the effect of a number of group I, II and III metabotropic glutamate (mGlu) receptor agonists and antagonists on paired pulse depression in the medial perforant path of the rat dentate gyrus in vitro. A triphasic pattern of a large depression at short intervals (10–50 ms), a red...