Sour Sensing from the Tongue to the Brain

• Published in: Cell Vol. 179; no. 2; pp. 392 - 402.e15
• Main Authors: Zhang, Jin, Jin, Hao, Zhang, Wenyi, Ding, Cheng, O’Keeffe, Sean, Ye, Mingyu, Zuker, Charles S.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 03.10.2019
• Subjects: Acids - pharmacology; Afferent Pathways - cytology; Afferent Pathways - metabolism; Afferent Pathways - physiology; Animals; brain; Brain - cytology; Brain - metabolism; Brain - physiology; brain circuits; Female; fermentation; ganglia; gravity; innate behaviors; ion channels; Male; Membrane Proteins - genetics; Membrane Proteins - metabolism; Mice; Mice, Inbred C57BL; otopetrin; sensory coding; sour; sourness; Taste; Taste Buds - drug effects; Taste Buds - metabolism; Taste Buds - physiology; Taste Perception; taste receptors; tongue; brain circuits; sour; sensory coding; innate behaviors; otopetrin; taste
• ISSN: 0092-8674; 1097-4172; 1097-4172
• DOI: 10.1016/j.cell.2019.08.031

The ability to sense sour provides an important sensory signal to prevent the ingestion of unripe, spoiled, or fermented foods. Taste and somatosensory receptors in the oral cavity trigger aversive behaviors in response to acid stimuli. Here, we show that the ion channel Otopetrin-1, a proton-select...