DUSP26 regulates podocyte oxidative stress and fibrosis in a mouse model with diabetic nephropathy through the mediation of ROS

• Published in: Biochemical and biophysical research communications Vol. 515; no. 3; pp. 410 - 416
• Main Authors: Huang, Feng, Sheng, Xu-Xiang, Zhang, Hong-Juan
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 30.07.2019
• Subjects: animal models; apoptosis; basement membrane; cell growth; cortex; diabetic nephropathy; Diabetic nephropathy (DN); DUSP26; fibrosis; gene targeting; glucose; hydrogen peroxide; inflammation; kidneys; mice; mitogen-activated protein kinase; oxidative stress; patients; Podocyte injury; renal failure; ROS; streptozotocin; superoxide dismutase; TGF-β1 and MAPKs; therapeutics; transforming growth factor beta 1; Diabetic nephropathy (DN); Podocyte injury; DUSP26; ROS; TGF-β1 and MAPKs

Diabetic nephropathy (DN) is a leading cause of renal failure worldwide. Unfortunately, the pathogenetic mechanism of DN is far from to be understood. Dual-specificity phosphatase 26 (DUSP26) is a member of the Dusp protein family, and is suggested to be involved in divers biological and pathologica...