Glycosphingolipids in engineered mice: insights into function

Recent success in the cloning of glycosyl-transferase genes involved in the synthesis of GSLs has enabled us to modulate the expression profiles of GSLs in cultured cells and experimental animals, and allowed novel approaches to obtain clear elucidation of individual enzyme products by observing the...

Full description

Saved in:
Bibliographic Details
Published inSeminars in cell & developmental biology Vol. 15; no. 4; pp. 389 - 396
Main Authors Furukawa, Koichi, Tokuda, Noriyo, Okuda, Tetsuya, Tajima, Orie, Furukawa, Keiko
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.08.2004
Subjects
Animals
Disease model
Glycosphingolipids
Glycosphingolipids - biosynthesis
Glycosphingolipids - genetics
Glycosphingolipids - physiology
Glycosyltransferase
Glycosyltransferases - metabolism
Knock-out
Mice
Mice, Knockout
Mutant
Nerve Regeneration
Raft
Signal Transduction
Targeting
Glycosphingolipids
Targeting
Glycosyltransferase
Mutant
Raft
Knock-out
Disease model
Online AccessGet full text

Cover

More Information
Summary:Recent success in the cloning of glycosyl-transferase genes involved in the synthesis of GSLs has enabled us to modulate the expression profiles of GSLs in cultured cells and experimental animals, and allowed novel approaches to obtain clear elucidation of individual enzyme products by observing the resulting phenotypic changes in the mutant animals and transfected cells. In this review, recent progress in the study of glycosyltransferases involved in the synthesis and modification of GSLs has been summarized with special emphasis on their function.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ObjectType-Feature-3
ObjectType-Review-1
ISSN:1084-9521
1096-3634
DOI:10.1016/j.semcdb.2004.03.006