Structural basis of mapping the spontaneous mutations with 5-flurouracil in uracil phosphoribosyltransferase from Mycobacterium tuberculosis

• Published in: Biochemical and biophysical research communications Vol. 467; no. 3; pp. 577 - 582
• Main Authors: Ghode, Pramila, Jobichen, Chacko, Ramachandran, Sarath, Bifani, Pablo, Sivaraman, J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 20.11.2015
• Subjects: 5-fluorouracil (5-FU); Amino Acid Sequence; Fluorouracil - pharmacology; Molecular Sequence Data; Mutation; Mycobacterium tuberculosis; Mycobacterium tuberculosis (Mtb); Mycobacterium tuberculosis - enzymology; Mycobacterium tuberculosis - genetics; Pentosyltransferases - chemistry; Pentosyltransferases - genetics; Pentosyltransferases - metabolism; Sequence Homology, Amino Acid; Spontaneous mutants; upp (Rv3309c); Uracil phosphoribosyltransferase (UPRT); 5-fluorouracil (5-FU); Uracil phosphoribosyltransferase (UPRT); upp (Rv3309c); Mycobacterium tuberculosis (Mtb); Spontaneous mutants

Tuberculosis (TB) remains the second leading cause of death from an infectious disease globally, despite the incessant efforts to control it. Research and development into new TB medicines is imperative for effective TB control; however, new strategies for the rational use of existing drugs, such as...