Crucial players in glycolysis: Cancer progress
•Since there is no exact cure discovered for cancer, studies have focused on different hallmarks of cancer.•Warburg’s hypothesis has been a step for the studies in this subject.•With the knowledge of crucial players in glycolysis takes place in cancer cells, therapies will be more accurate. Cancer i...
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| Published in | Gene Vol. 726; p. 144158 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
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Elsevier B.V
05.02.2020
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| Abstract | •Since there is no exact cure discovered for cancer, studies have focused on different hallmarks of cancer.•Warburg’s hypothesis has been a step for the studies in this subject.•With the knowledge of crucial players in glycolysis takes place in cancer cells, therapies will be more accurate.
Cancer is the second most important cause of death and new therapy modalities continue to be developed and evolved. Cancer cells’ metabolism is far different from the normal, healthy cells; they are more metabolically active, have higher proliferation rate and could able to resist to cell death pathways like apoptosis. It is known that in addition to increasing the expression of enzymes that are crucial in glycolysis for much more energy production, cancer cells produce energy from lactic acid fermentation after glycolysis. In 1920s, Warburg has claimed that cancer cells are more active in glycolysis than normal cells and use much more glucose in order to obtain more ATP for metabolic activities, then this is named as Warburg effect. After that; new methodologies and therapeutics that target metabolism, began to be attractive subject in cancer studies. Therefore, the main genes, enzymes and factors are begun to investigate and further studied for understanding their roles in metabolism of cancer cells. |
|---|---|
| AbstractList | Cancer is the second most important cause of death and new therapy modalities continue to be developed and evolved. Cancer cells’ metabolism is far different from the normal, healthy cells; they are more metabolically active, have higher proliferation rate and could able to resist to cell death pathways like apoptosis. It is known that in addition to increasing the expression of enzymes that are crucial in glycolysis for much more energy production, cancer cells produce energy from lactic acid fermentation after glycolysis. In 1920s, Warburg has claimed that cancer cells are more active in glycolysis than normal cells and use much more glucose in order to obtain more ATP for metabolic activities, then this is named as Warburg effect. After that; new methodologies and therapeutics that target metabolism, began to be attractive subject in cancer studies. Therefore, the main genes, enzymes and factors are begun to investigate and further studied for understanding their roles in metabolism of cancer cells. •Since there is no exact cure discovered for cancer, studies have focused on different hallmarks of cancer.•Warburg’s hypothesis has been a step for the studies in this subject.•With the knowledge of crucial players in glycolysis takes place in cancer cells, therapies will be more accurate. Cancer is the second most important cause of death and new therapy modalities continue to be developed and evolved. Cancer cells’ metabolism is far different from the normal, healthy cells; they are more metabolically active, have higher proliferation rate and could able to resist to cell death pathways like apoptosis. It is known that in addition to increasing the expression of enzymes that are crucial in glycolysis for much more energy production, cancer cells produce energy from lactic acid fermentation after glycolysis. In 1920s, Warburg has claimed that cancer cells are more active in glycolysis than normal cells and use much more glucose in order to obtain more ATP for metabolic activities, then this is named as Warburg effect. After that; new methodologies and therapeutics that target metabolism, began to be attractive subject in cancer studies. Therefore, the main genes, enzymes and factors are begun to investigate and further studied for understanding their roles in metabolism of cancer cells. Cancer is the second most important cause of death and new therapy modalities continue to be developed and evolved. Cancer cells' metabolism is far different from the normal, healthy cells; they are more metabolically active, have higher proliferation rate and could able to resist to cell death pathways like apoptosis. It is known that in addition to increasing the expression of enzymes that are crucial in glycolysis for much more energy production, cancer cells produce energy from lactic acid fermentation after glycolysis. In 1920s, Warburg has claimed that cancer cells are more active in glycolysis than normal cells and use much more glucose in order to obtain more ATP for metabolic activities, then this is named as Warburg effect. After that; new methodologies and therapeutics that target metabolism, began to be attractive subject in cancer studies. Therefore, the main genes, enzymes and factors are begun to investigate and further studied for understanding their roles in metabolism of cancer cells.Cancer is the second most important cause of death and new therapy modalities continue to be developed and evolved. Cancer cells' metabolism is far different from the normal, healthy cells; they are more metabolically active, have higher proliferation rate and could able to resist to cell death pathways like apoptosis. It is known that in addition to increasing the expression of enzymes that are crucial in glycolysis for much more energy production, cancer cells produce energy from lactic acid fermentation after glycolysis. In 1920s, Warburg has claimed that cancer cells are more active in glycolysis than normal cells and use much more glucose in order to obtain more ATP for metabolic activities, then this is named as Warburg effect. After that; new methodologies and therapeutics that target metabolism, began to be attractive subject in cancer studies. Therefore, the main genes, enzymes and factors are begun to investigate and further studied for understanding their roles in metabolism of cancer cells. |
| ArticleNumber | 144158 |
| Author | Çeşmeli, Selin Biray Avcı, Çığır Abbaszadeh, Zaka |
| Author_xml | – sequence: 1 givenname: Zaka surname: Abbaszadeh fullname: Abbaszadeh, Zaka – sequence: 2 givenname: Selin surname: Çeşmeli fullname: Çeşmeli, Selin email: selcesmeli.sc@gmail.com – sequence: 3 givenname: Çığır surname: Biray Avcı fullname: Biray Avcı, Çığır |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31629815$$D View this record in MEDLINE/PubMed |
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| Snippet | •Since there is no exact cure discovered for cancer, studies have focused on different hallmarks of cancer.•Warburg’s hypothesis has been a step for the... Cancer is the second most important cause of death and new therapy modalities continue to be developed and evolved. Cancer cells' metabolism is far different... Cancer is the second most important cause of death and new therapy modalities continue to be developed and evolved. Cancer cells’ metabolism is far different... |
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| SubjectTerms | Adenosine Triphosphate - metabolism Animals apoptosis Apoptosis - physiology biochemical pathways Cancer death Disease Progression energy enzymes genes Glcolysis glucose Glucose - metabolism glycolysis Glycolysis - physiology Glycolytic enzymes Humans Lactic Acid - metabolism lactic fermentation methodology Mitochondria - metabolism Mitochondria - pathology neoplasm cells Neoplasms - metabolism Neoplasms - pathology Oxidative phosphorylation (OXPHOS) therapeutics |
| Title | Crucial players in glycolysis: Cancer progress |
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