Genetic control of low-density-lipoprotein subclasses

• Published in: The Lancet (British edition) Vol. 2; no. 8507; p. 592
• Main Authors: Austin, M A, Krauss, R M
• Format: Journal Article
• Language: English
• Published: England 13.09.1986
• Subjects: Adolescent; Adult; Age Factors; Aged; Alleles; Apoproteins - blood; Child; Chromosome Mapping; Electrophoresis, Agar Gel; Female; Humans; Lipids - blood; Lipoproteins, LDL - blood; Lipoproteins, LDL - classification; Lipoproteins, LDL - genetics; Middle Aged; Models, Theoretical; Pedigree; Phenotype; Triglycerides - blood

In a study of lipoprotein subclasses in 79 healthy members of sixteen nuclear families evidence was obtained that low-density-lipoprotein (LDL) subclass patterns determined by gradient-gel electrophoresis are influenced by a common allele at a single genetic locus. The estimated frequency of the all...