Insights into cancer therapeutic design based on p53 and TRAIL receptor signaling

• Published in: Cell death and differentiation Vol. 8; no. 11; pp. 1066 - 1075
• Main Author: El-Deiry, W S
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.11.2001
• Subjects: Animals; Apoptosis; Apoptosis - physiology; Apoptosis Regulatory Proteins; Cancer therapies; Cell cycle; Cell death; Chemotherapy; Drug Design; Humans; Ligands; Membrane Glycoproteins - metabolism; Mutation; Neoplasms - drug therapy; Oncology; Proteins; Radiation therapy; Receptors, TNF-Related Apoptosis-Inducing Ligand; Receptors, Tumor Necrosis Factor - genetics; Signal Transduction - physiology; TNF-Related Apoptosis-Inducing Ligand; Toxicity; TRAIL protein; Tumor Necrosis Factor-alpha - metabolism; Tumor necrosis factor-TNF; Tumor Suppressor Protein p53 - genetics; Tumor Suppressor Protein p53 - metabolism; Tumors; United States > US

Knowledge of the emerging pathways of cell death downstream of the p53 tumor suppressor and the TRAIL death-inducing ligand is suggesting ways to improve therapeutic design in cancer. In contrast to its unique G1 cell cycle arresting mechanism that is maintained by p21(WAF1), there are signals trans...