S-531011, a Novel Anti-Human CCR8 Antibody, Induces Potent Antitumor Responses through Depletion of Tumor-Infiltrating CCR8-Expressing Regulatory T Cells

• Published in: Molecular cancer therapeutics Vol. 22; no. 9; pp. 1063 - 1072
• Main Authors: Nagira, Yoji, Nagira, Morio, Nagai, Ryohei, Nogami, Wataru, Hirata, Michinari, Ueyama, Azumi, Yoshida, Tetsuya, Yoshikawa, Mai, Shinonome, Satomi, Yoshida, Hiroshi, Haruna, Miya, Miwa, Hiroto, Chatani, Natsumi, Ohkura, Naganari, Wada, Hisashi, Tanaka, Hidekazu
• Format: Journal Article
• Language: English
• Published: American Association for Cancer Research 05.09.2023
• Subjects: Large Molecule Therapeutics

Although regulatory T cells (Treg) are inhibitory immune cells that are essential for maintaining immune homeostasis, Tregs that infiltrate tumor tissue promote tumor growth by suppressing antitumor immunity. Selective reduction of tumor-infiltrating Tregs is, therefore, expected to activate antitum...