Mitochondrial dysfunction in dopaminergic neurons differentiated from exfoliated deciduous tooth-derived pulp stem cells of a child with Rett syndrome

• Published in: Biochemical and biophysical research communications Vol. 498; no. 4; pp. 898 - 904
• Main Authors: Hirofuji, Saki, Hirofuji, Yuta, Kato, Hiroki, Masuda, Keiji, Yamaza, Haruyoshi, Sato, Hiroshi, Takayama, Fumiko, Torio, Michiko, Sakai, Yasunari, Ohga, Shouichi, Taguchi, Tomoaki, Nonaka, Kazuaki
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.04.2018
• Subjects: adenosine triphosphate; autism; biogenic amines; branching; cell proliferation; children; Deciduous tooth; Dental pulp stem cell; DNA-binding domains; Dopaminergic neuron; genes; girls; isolation techniques; membrane potential; mitochondria; mitochondrial membrane; Mitochondrion; neurites; nuclear localization signals; patients; pulp; Rett syndrome; signal transduction; stem cells; teeth; transcription (genetics); Mitochondrion; MeCP2; MMP; SHED; RTT; Dental pulp stem cell; Deciduous tooth; Rett syndrome; Dopaminergic neuron; DN; XCI

Rett syndrome is an X-linked neurodevelopmental disorder associated with psychomotor impairments, autonomic dysfunctions and autism. Patients with Rett syndrome have loss-of-function mutations in MECP2, the gene encoding methyl-CpG-binding protein 2 (MeCP2). Abnormal biogenic amine signaling and mit...