There is an association between a genetic polymorphism in the ZNF259 gene involved in lipid metabolism and coronary artery disease

• Published in: Gene Vol. 704; pp. 80 - 85
• Main Authors: Mirhafez, Seyed Reza, Avan, Amir, Khatamianfar, Sara, Ghasemi, Faezeh, Moohebati, Mohsen, Ebrahimi, Mahmoud, Ghazizadeh, Hamideh, Ghayour-Mobarhan, Majid, Pasdar, Alireza
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.07.2019
• Subjects: Adult; Aged; alleles; blood glucose; C-reactive protein; Carrier Proteins - genetics; Case-Control Studies; Cholesterol Ester Transfer Proteins - genetics; Coronary artery disease; Coronary Artery Disease - epidemiology; Coronary Artery Disease - genetics; Coronary Artery Disease - metabolism; Epistasis, Genetic - physiology; Female; Gene Frequency; Genetic Predisposition to Disease; genetic variation; Genome-Wide Association Study; genotype; genotyping; Humans; hyperlipidemia; Iran - epidemiology; lipid composition; Lipid metabolism; Lipid Metabolism - genetics; low density lipoprotein cholesterol; Male; Middle Aged; patients; Polymorphism, Single Nucleotide; quantitative polymerase chain reaction; risk assessment; Risk Factors; Single nucleotide polymorphism; waist circumference; Zink finger protein; Iran; CRP; CETP; GWAS; lipoprotein; LPL; IDF; FBG; CELSR2; HDL-C; SD; MYBPHL; LDL; VLDL; SNPs; Lipid metabolism; BMI; Zink finger protein; CE; SORT1; 3′UTR; CAD; MUMS; SBP or DBP; APOA5; Coronary artery disease; TG; PSRC1; ZNF259; Single nucleotide polymorphism; LPA

Recent genome-wide association studies (GWAS) have identified several genetic variants that influence the risk of dyslipidemia and coronary artery disease (CAD). In this study, we have examined the potential association of five SNPs variants related to lipid pathway, previously identified in GWAS st...