There is an association between a genetic polymorphism in the ZNF259 gene involved in lipid metabolism and coronary artery disease

• Published in: Gene Vol. 704; pp. 80 - 85
• Main Authors: Mirhafez, Seyed Reza, Avan, Amir, Khatamianfar, Sara, Ghasemi, Faezeh, Moohebati, Mohsen, Ebrahimi, Mahmoud, Ghazizadeh, Hamideh, Ghayour-Mobarhan, Majid, Pasdar, Alireza
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.07.2019
• Subjects: Adult; Aged; alleles; blood glucose; C-reactive protein; Carrier Proteins - genetics; Case-Control Studies; Cholesterol Ester Transfer Proteins - genetics; Coronary artery disease; Coronary Artery Disease - epidemiology; Coronary Artery Disease - genetics; Coronary Artery Disease - metabolism; Epistasis, Genetic - physiology; Female; Gene Frequency; Genetic Predisposition to Disease; genetic variation; Genome-Wide Association Study; genotype; genotyping; Humans; hyperlipidemia; Iran - epidemiology; lipid composition; Lipid metabolism; Lipid Metabolism - genetics; low density lipoprotein cholesterol; Male; Middle Aged; patients; Polymorphism, Single Nucleotide; quantitative polymerase chain reaction; risk assessment; Risk Factors; Single nucleotide polymorphism; waist circumference; Zink finger protein; Iran; CRP; CETP; GWAS; lipoprotein; LPL; IDF; FBG; CELSR2; HDL-C; SD; MYBPHL; LDL; VLDL; SNPs; Lipid metabolism; BMI; Zink finger protein; CE; SORT1; 3′UTR; CAD; MUMS; SBP or DBP; APOA5; Coronary artery disease; TG; PSRC1; ZNF259; Single nucleotide polymorphism; LPA
• ISSN: 0378-1119; 1879-0038; 1879-0038
• DOI: 10.1016/j.gene.2019.02.101

Recent genome-wide association studies (GWAS) have identified several genetic variants that influence the risk of dyslipidemia and coronary artery disease (CAD). In this study, we have examined the potential association of five SNPs variants related to lipid pathway, previously identified in GWAS studies (ZNF259 C>G, CETP I405VA/G, LPA C>T, LPLS447X and PSRC1 A>G) with CAD. Two hundred and ninety subjects including 194 patients with coronary artery disease and 96 controls were enrolled, followed by the analyses of anthropometric/biochemical parameters. Genotyping was carried out using Taq-Man real-time PCR based method. The association of the genetic polymorphisms with CAD was determined using univariate and multivariate analyses. CAD patients had a higher (p < 0.05) fasting blood glucose (FBG), total cholesterol (TC), high sensitivity C-reactive protein (hs-CRP), low-density lipoprotein cholesterol (LDL-C) and waist circumference. Results showed that subjects with CETP rs5882 genetic variant, AA&AG genotypes, had a higher risk of developing Coronary artery disease [OR: 2.1, 95% CI (1.2–4.1), p value = 0.015]. Also subjects who carried the G allele of the ZNF259 polymorphism were at an increased the risk of developing CAD [OR 1.86, 95% CI: 1.06–3.25, p value = 0.029] and had an increased TC, LDL and TG levels (p < 0.05). Furthermore, no statistically significant association was found between genetic polymorphisms of PSRC1 A>G, LPL S447X and LPA C>T and CAD. We identified a relationship between a genetic variant in CETP and ZNF259 gene with CAD and CAD and lipid profile, respectively. Further investigation in a larger population may help to investigate the value of emerging marker as a risk stratification marker in CAD and its risk factors. •To examine the potential association of five SNPs variants related to lipid pathway with CAD.•A total of 290 subjects including 194 patients with CAD and 96 controls were enrolled.•There was an association between CETP rs5882 SNP (AA&AG genotypes) with high risk of CAD•The G allele of ZNF259 SNP had an association with CAD and an increased TC, LDL and TG levels.•No significant association was found between SNPs of PSRC1 A>G, LPL S447X and LPA C>T and CAD.