Long non-coding RNA FTH1P3 facilitates oral squamous cell carcinoma progression by acting as a molecular sponge of miR-224-5p to modulate fizzled 5 expression

• Published in: Gene Vol. 607; pp. 47 - 55
• Main Author: Zhang, Chen-Zheng
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 05.04.2017
• Subjects: carcinogenesis; Carcinoma, Squamous Cell - genetics; Carcinoma, Squamous Cell - mortality; Carcinoma, Squamous Cell - pathology; Cell Line, Tumor; cell proliferation; ferritin; Ferritin heavy chain 1 pseudogene 3 (FTH1P3); Fizzled 5; Frizzled Receptors - genetics; gene expression regulation; Gene Expression Regulation, Neoplastic; gene overexpression; Humans; Kaplan-Meier Estimate; MicroRNAs - genetics; miR-224-5p; Mouth Neoplasms - genetics; Mouth Neoplasms - mortality; Mouth Neoplasms - pathology; non-coding RNA; oncogenes; Oral squamous cell carcinoma (OSCC); patients; pseudogenes; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; RNA, Long Noncoding - genetics; squamous cell carcinoma; survival rate; tissues; Tumorigenesis; lncRNAs; OSCC; ceRNA; miR-224-5p; Oral squamous cell carcinoma (OSCC); ANOVA; Fizzled 5; Ferritin heavy chain 1 pseudogene 3 (FTH1P3); Tumorigenesis; EMT; FTH1P3

A growing body of evidence has indicated that long non-coding RNAs (lncRNAs) function as competing endogenous RNAs (ceRNAs) during tumorigenesis. In this study, the qRT-PCR results revealed that the lncRNA ferritin heavy chain 1 pseudogene 3 (FTH1P3) was over-expressed in oral squamous cell carcinom...