Ecotoxicological effect of ketoconazole on the antioxidant system of Daphnia similis

The occurrence of emerging pharmaceutical pollutants (i.e. small drugs, antibiotics) present in aquatic environments shown to be a current environmental problem still without apparent solution. In this regard, the use of ecotoxicological techniques has been shown fundamental for the appraisal of dam...

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Published inComparative biochemistry and physiology. Toxicology & pharmacology Vol. 246; p. 109080
Main Authors do Prado, Caio César Achiles, Queiroz, Lucas Gonçalves, da Silva, Flávio Teixeira, de Paiva, Teresa Cristina Brazil
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.08.2021
Subjects
Aquatic toxicity
ascorbate peroxidase
biomarkers
catalase
Daphnia similis
Daphnids
ecotoxicology
glutathione transferase
ketoconazole
Oxidative stress biomarkers
Pharmaceutical contaminants
physiology
reproductive system
Aquatic toxicity
Pharmaceutical contaminants
Oxidative stress biomarkers
Daphnids
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Abstract The occurrence of emerging pharmaceutical pollutants (i.e. small drugs, antibiotics) present in aquatic environments shown to be a current environmental problem still without apparent solution. In this regard, the use of ecotoxicological techniques has been shown fundamental for the appraisal of damage to affected living organisms. Herein, ecotoxicological tests were conducted, focusing on the evaluation of the effects of ketoconazole (KTZ) on the antioxidant system of the model body Daphnia similis. In order to study the biochemical changes caused by KTZ in the antioxidant system, the enzymatic biomarkers glutathione S-transferase (GST), catalase (CAT), and ascorbate peroxidase (APX) were monitored. Toxicological tests were conducted using KTZ concentrations (0–10 μg·L−1). Prolonged exposure to KTZ (336 h) caused changes upon the expression of antioxidant enzymes and simultaneously affected the reproductive system in those organisms. Moreover, a decrease in GST and APX activity was observed caused by KTZ exposure, respectively 79.2% (3.53 μmol min−1 mg−1 protein) and 24.4% (0.88 μmol min−1 mg−1 protein). On the other hand, it was observed an increase of 27% (0.17 μmol min−1 mg−1 protein) in CAT activity. Through this study, it was possible to observe the toxicological effects of KTZ, which proves its action as an oxidative stress-inducing agent and endocrine modifier in daphnids organisms. [Display omitted] •Pharmacological products present toxic risks to biota from aquatic environments.•Daphnia similis is sensitive to low doses of KTZ (<2.08 μg·L−1).•KTZ (<0.32 μg·L−1) promoted a modification in the enzymatic responses of D. similis.•KTZ toxicity showed greater damage to GST activity (79% reduction in the activity).•KTZ showed induction of reproductive activity in D. similis.
AbstractList The occurrence of emerging pharmaceutical pollutants (i.e. small drugs, antibiotics) present in aquatic environments shown to be a current environmental problem still without apparent solution. In this regard, the use of ecotoxicological techniques has been shown fundamental for the appraisal of damage to affected living organisms. Herein, ecotoxicological tests were conducted, focusing on the evaluation of the effects of ketoconazole (KTZ) on the antioxidant system of the model body Daphnia similis. In order to study the biochemical changes caused by KTZ in the antioxidant system, the enzymatic biomarkers glutathione S-transferase (GST), catalase (CAT), and ascorbate peroxidase (APX) were monitored. Toxicological tests were conducted using KTZ concentrations (0-10 μg·L ). Prolonged exposure to KTZ (336 h) caused changes upon the expression of antioxidant enzymes and simultaneously affected the reproductive system in those organisms. Moreover, a decrease in GST and APX activity was observed caused by KTZ exposure, respectively 79.2% (3.53 μmol min  mg protein) and 24.4% (0.88 μmol min  mg protein). On the other hand, it was observed an increase of 27% (0.17 μmol min  mg protein) in CAT activity. Through this study, it was possible to observe the toxicological effects of KTZ, which proves its action as an oxidative stress-inducing agent and endocrine modifier in daphnids organisms.
The occurrence of emerging pharmaceutical pollutants (i.e. small drugs, antibiotics) present in aquatic environments shown to be a current environmental problem still without apparent solution. In this regard, the use of ecotoxicological techniques has been shown fundamental for the appraisal of damage to affected living organisms. Herein, ecotoxicological tests were conducted, focusing on the evaluation of the effects of ketoconazole (KTZ) on the antioxidant system of the model body Daphnia similis. In order to study the biochemical changes caused by KTZ in the antioxidant system, the enzymatic biomarkers glutathione S-transferase (GST), catalase (CAT), and ascorbate peroxidase (APX) were monitored. Toxicological tests were conducted using KTZ concentrations (0–10 μg·L⁻¹). Prolonged exposure to KTZ (336 h) caused changes upon the expression of antioxidant enzymes and simultaneously affected the reproductive system in those organisms. Moreover, a decrease in GST and APX activity was observed caused by KTZ exposure, respectively 79.2% (3.53 μmol min⁻¹ mg⁻¹ protein) and 24.4% (0.88 μmol min⁻¹ mg⁻¹ protein). On the other hand, it was observed an increase of 27% (0.17 μmol min⁻¹ mg⁻¹ protein) in CAT activity. Through this study, it was possible to observe the toxicological effects of KTZ, which proves its action as an oxidative stress-inducing agent and endocrine modifier in daphnids organisms.
The occurrence of emerging pharmaceutical pollutants (i.e. small drugs, antibiotics) present in aquatic environments shown to be a current environmental problem still without apparent solution. In this regard, the use of ecotoxicological techniques has been shown fundamental for the appraisal of damage to affected living organisms. Herein, ecotoxicological tests were conducted, focusing on the evaluation of the effects of ketoconazole (KTZ) on the antioxidant system of the model body Daphnia similis. In order to study the biochemical changes caused by KTZ in the antioxidant system, the enzymatic biomarkers glutathione S-transferase (GST), catalase (CAT), and ascorbate peroxidase (APX) were monitored. Toxicological tests were conducted using KTZ concentrations (0-10 μg·L-1). Prolonged exposure to KTZ (336 h) caused changes upon the expression of antioxidant enzymes and simultaneously affected the reproductive system in those organisms. Moreover, a decrease in GST and APX activity was observed caused by KTZ exposure, respectively 79.2% (3.53 μmol min-1 mg-1 protein) and 24.4% (0.88 μmol min-1 mg-1 protein). On the other hand, it was observed an increase of 27% (0.17 μmol min-1 mg-1 protein) in CAT activity. Through this study, it was possible to observe the toxicological effects of KTZ, which proves its action as an oxidative stress-inducing agent and endocrine modifier in daphnids organisms.The occurrence of emerging pharmaceutical pollutants (i.e. small drugs, antibiotics) present in aquatic environments shown to be a current environmental problem still without apparent solution. In this regard, the use of ecotoxicological techniques has been shown fundamental for the appraisal of damage to affected living organisms. Herein, ecotoxicological tests were conducted, focusing on the evaluation of the effects of ketoconazole (KTZ) on the antioxidant system of the model body Daphnia similis. In order to study the biochemical changes caused by KTZ in the antioxidant system, the enzymatic biomarkers glutathione S-transferase (GST), catalase (CAT), and ascorbate peroxidase (APX) were monitored. Toxicological tests were conducted using KTZ concentrations (0-10 μg·L-1). Prolonged exposure to KTZ (336 h) caused changes upon the expression of antioxidant enzymes and simultaneously affected the reproductive system in those organisms. Moreover, a decrease in GST and APX activity was observed caused by KTZ exposure, respectively 79.2% (3.53 μmol min-1 mg-1 protein) and 24.4% (0.88 μmol min-1 mg-1 protein). On the other hand, it was observed an increase of 27% (0.17 μmol min-1 mg-1 protein) in CAT activity. Through this study, it was possible to observe the toxicological effects of KTZ, which proves its action as an oxidative stress-inducing agent and endocrine modifier in daphnids organisms.
The occurrence of emerging pharmaceutical pollutants (i.e. small drugs, antibiotics) present in aquatic environments shown to be a current environmental problem still without apparent solution. In this regard, the use of ecotoxicological techniques has been shown fundamental for the appraisal of damage to affected living organisms. Herein, ecotoxicological tests were conducted, focusing on the evaluation of the effects of ketoconazole (KTZ) on the antioxidant system of the model body Daphnia similis. In order to study the biochemical changes caused by KTZ in the antioxidant system, the enzymatic biomarkers glutathione S-transferase (GST), catalase (CAT), and ascorbate peroxidase (APX) were monitored. Toxicological tests were conducted using KTZ concentrations (0–10 μg·L−1). Prolonged exposure to KTZ (336 h) caused changes upon the expression of antioxidant enzymes and simultaneously affected the reproductive system in those organisms. Moreover, a decrease in GST and APX activity was observed caused by KTZ exposure, respectively 79.2% (3.53 μmol min−1 mg−1 protein) and 24.4% (0.88 μmol min−1 mg−1 protein). On the other hand, it was observed an increase of 27% (0.17 μmol min−1 mg−1 protein) in CAT activity. Through this study, it was possible to observe the toxicological effects of KTZ, which proves its action as an oxidative stress-inducing agent and endocrine modifier in daphnids organisms. [Display omitted] •Pharmacological products present toxic risks to biota from aquatic environments.•Daphnia similis is sensitive to low doses of KTZ (<2.08 μg·L−1).•KTZ (<0.32 μg·L−1) promoted a modification in the enzymatic responses of D. similis.•KTZ toxicity showed greater damage to GST activity (79% reduction in the activity).•KTZ showed induction of reproductive activity in D. similis.
ArticleNumber 109080
Author da Silva, Flávio Teixeira
Queiroz, Lucas Gonçalves
de Paiva, Teresa Cristina Brazil
do Prado, Caio César Achiles
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  surname: do Prado
  fullname: do Prado, Caio César Achiles
  email: caioachiles@usp.br
  organization: Engineering School of Lorena, University of Sao Paulo, Department of Biotechnology, Lorena 12602-810, Brazil
– sequence: 2
  givenname: Lucas Gonçalves
  surname: Queiroz
  fullname: Queiroz, Lucas Gonçalves
  email: lucasgoncalvesqueiroz@gmail.com
  organization: Engineering School of Lorena, University of Sao Paulo, Department of Biotechnology, Lorena 12602-810, Brazil
– sequence: 3
  givenname: Flávio Teixeira
  surname: da Silva
  fullname: da Silva, Flávio Teixeira
  email: flavio@debiq.eel.usp.br
  organization: Engineering School of Lorena, University of Sao Paulo, Department of Biotechnology, Lorena 12602-810, Brazil
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  givenname: Teresa Cristina Brazil
  surname: de Paiva
  fullname: de Paiva, Teresa Cristina Brazil
  email: teresa@debiq.eel.usp.br
  organization: Engineering School of Lorena, University de Sao Paulo, Department of Basic and Environmental Sciences, Lorena 12602-810, Brazil
BackLink https://www.ncbi.nlm.nih.gov/pubmed/34015536$$D View this record in MEDLINE/PubMed
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Keywords Aquatic toxicity
Pharmaceutical contaminants
Oxidative stress biomarkers
Daphnids
Language English
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Snippet The occurrence of emerging pharmaceutical pollutants (i.e. small drugs, antibiotics) present in aquatic environments shown to be a current environmental...
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SubjectTerms Aquatic toxicity
ascorbate peroxidase
biomarkers
catalase
Daphnia similis
Daphnids
ecotoxicology
glutathione transferase
ketoconazole
Oxidative stress biomarkers
Pharmaceutical contaminants
physiology
reproductive system
Title Ecotoxicological effect of ketoconazole on the antioxidant system of Daphnia similis
URI https://dx.doi.org/10.1016/j.cbpc.2021.109080
https://www.ncbi.nlm.nih.gov/pubmed/34015536
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https://www.proquest.com/docview/2551928922
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