Correlation of in vitro and in vivo acetaminophen availability from albumin microaggregates oral modified release formulations

• Published in: International journal of pharmaceutics Vol. 217; no. 1; pp. 193 - 199
• Main Authors: Torrado, G., Carrascosa, C., Torrado-Santiago, S.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 17.04.2001; Elsevier
• Subjects: Acetaminophen; Acetaminophen - chemistry; Acetaminophen - pharmacokinetics; Acetaminophen - urine; Administration, Oral; Adult; Albumin microaggregates; Analgesics, Non-Narcotic - chemistry; Analgesics, Non-Narcotic - pharmacokinetics; Analgesics, Non-Narcotic - urine; Biological and medical sciences; Biological Availability; Chemistry, Pharmaceutical; Female; General pharmacology; Humans; Intestinal Absorption; Male; Medical sciences; Ovalbumin - chemistry; Ovalbumin - pharmacokinetics; Ovalbumin - urine; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Saliva - metabolism; Site-specific drug delivery; Acetaminophen; Albumin microaggregates; Site-specific drug delivery; Human; Urine; Pharmaceutical technology; Healthy subject; Controlled release form; Oral administration; Albumin; Oral form; Drug carrier; Dissolution; In vitro; Blood; Matrix tablet; Blood plasma; Paracetamol; Dosage form; Tablet; Aggregate; Pharmacokinetics; Saliva; Release; Physicochemical properties

The aim of this study was to develop albumin microaggregated oral formulations for controlled drug release, and to reveal the possible influence of the release site on drug absorption. Acetaminophen was chosen as the model drug, which is included in the Class 1 group of the Biopharmaceutics Classifi...