Effect of Remifentanil on Pain and Secondary Hyperalgesia Associated with the Heat–Capsaicin Sensitization Model in Healthy Volunteers

• Published in: Anesthesiology (Philadelphia) Vol. 94; no. 1; pp. 15 - 20
• Main Authors: Petersen, Karin L., Jones, Bruce, Segredo, Veronica, Dahl, Jørgen B., Rowbotham, Michael C.
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott 01.01.2001
• Subjects: Adult; Analgesics; Analgesics, Opioid - therapeutic use; Biological and medical sciences; Capsaicin - adverse effects; Female; Hot Temperature - adverse effects; Humans; Hyperalgesia - drug therapy; Hyperalgesia - etiology; Male; Medical sciences; Middle Aged; Neuropharmacology; Pain Measurement; Pharmacology. Drug treatments; Piperidines - therapeutic use; Remifentanil; Human; Secondary; Healthy subject; Capsaicin; Opiates; Narcotic analgesic; Remifentanil; Hyperalgesia; Analgesia; Heat; Chemotherapy; Pain; Treatment; Models

The heat--capsaicin sensitization model was developed as a noninvasive and noninjurious human experimental pain model. The sequential application of moderate intensity thermal and topical chemical stimuli produces stable and long-lasting areas of cutaneous secondary hyperalgesia. The aim of the pres...