Bioenergetic Analysis of Single Pancreatic β-Cells Indicates an Impaired Metabolic Signature in Type 2 Diabetic Subjects

• Published in: Endocrinology (Philadelphia) Vol. 156; no. 10; pp. 3496 - 3503
• Main Author: Gerencser, Akos A.
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.10.2015
• Subjects: Beta cells; Blood Glucose - metabolism; Cell activation; Cells, Cultured; Depolarization; Diabetes; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - metabolism; Energy Metabolism; Gene Expression Regulation; Glucose; Glucose - metabolism; Humans; Hyperpolarization; Insulin; Insulin secretion; Insulin-Secreting Cells - metabolism; Islet cells; Islets of Langerhans - metabolism; Membrane potential; Membrane Potential, Mitochondrial; Membranes; Metabolic rate; Metabolism; Microscopy, Fluorescence; Mitochondria; Mitochondria - metabolism; Organ donors; Oxidative Stress; Pancreas; Synthesis; Tricarboxylic acid cycle

Impaired activation of mitochondrial energy metabolism by glucose has been demonstrated in type 2 diabetic β-cells. The cause of this dysfunction is unknown. The aim of this study was to identify segments of energy metabolism with normal or with altered function in human type 2 diabetes mellitus. Th...