A novel formulation of solubilised amphotericin B designed for ophthalmic use

• Published in: International journal of pharmaceutics Vol. 437; no. 1-2; pp. 80 - 82
• Main Authors: Serrano, D.R., Ruiz-Saldaña, H.K., Molero, G., Ballesteros, M.P., Torrado, J.J.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.11.2012
• Subjects: Amphotericin B; Amphotericin B - administration & dosage; Amphotericin B - chemistry; Antifungal activity; Antifungal Agents - administration & dosage; Antifungal Agents - chemistry; antifungal properties; Candida albicans; Candida albicans - drug effects; Cyclodextrins; developed countries; Eye drops; eyes; gamma-cyclodextrin; gamma-Cyclodextrins - administration & dosage; gamma-Cyclodextrins - chemistry; Ophthalmic Solutions - administration & dosage; Ophthalmic Solutions - chemistry; osmolarity; particle size; Solubility; solubilization; Stability; Antifungal activity; Eye drops; Cyclodextrins; Stability; Amphotericin B

Amphotericin B (AmB) is a wide spectrum antifungal with low incidence of clinical resistance. However, there are no licensed topical formulations with AmB in most developed countries. Extemporaneous preparations of AmB are frequently prepared from available marketed parenteral formulations. Herein,...