Inflammation-mediated deacetylation of the ribonuclease 1 promoter via histone deacetylase 2 in endothelial cells

• Published in: The FASEB journal Vol. 33; no. 8; p. 9017
• Main Authors: Bedenbender, Katrin, Scheller, Nicoletta, Fischer, Silvia, Leiting, Silke, Preissner, Klaus T, Schmeck, Bernd T, Vollmeister, Evelyn
• Format: Journal Article
• Language: English
• Published: United States 01.08.2019
• Subjects: MS275; TNF-α; histone acetylation; chromatin immunoprecipitation; vascular homeostasis

Ribonuclease 1 (RNase1) is a circulating extracellular endonuclease that regulates the vascular homeostasis of extracellular RNA and acts as a vessel- and tissue-protective enzyme. Upon long-term inflammation, high amounts of proinflammatory cytokines affect endothelial cell (EC) function by down-re...