Low vitamin D serum level is related to severe fibrosis and low responsiveness to interferon‐based therapy in genotype 1 chronic hepatitis C

• Published in: Hepatology (Baltimore, Md.) Vol. 51; no. 4; pp. 1158 - 1167
• Main Authors: Petta, Salvatore, Cammà, Calogero, Scazzone, Concetta, Tripodo, Claudio, Di Marco, Vito, Bono, Antonino, Cabibi, Daniela, Licata, Giusalba, Porcasi, Rossana, Marchesini, Giulio, Craxí, Antonio
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.04.2010; Wiley
• Subjects: Adult; Aged; Biological and medical sciences; Cholestanetriol 26-Monooxygenase - analysis; Cytochrome P450 Family 2; Female; Gastroenterology. Liver. Pancreas. Abdomen; Genotype; Hepacivirus - classification; Hepatitis C, Chronic - blood; Hepatitis C, Chronic - drug therapy; Hepatitis C, Chronic - virology; Human viral diseases; Humans; Infectious diseases; Interferons - therapeutic use; Liver Cirrhosis - blood; Liver Cirrhosis - etiology; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Male; Medical sciences; Middle Aged; Ribavirin - administration & dosage; Risk Factors; Viral diseases; Viral hepatitis; Vitamin D - analogs & derivatives; Vitamin D - blood; Typing; Cytokine; Hepatic disease; Genotype; Infection; Microbiological investigation; Treatment; Vitamin D; Viral disease; Fibrosis; Gastroenterology; Digestive diseases; Serum; Interferon; Viral hepatitis C

25‐Hydroxyvitamin D (25[OH]D) can potentially interfere with inflammatory response and fibrogenesis. Its role in disease progression in chronic hepatitis C (CHC) and its relation with histological and sustained virological response (SVR) to therapy are unknown. One hundred ninety‐seven patients with...