The expression of intestinal Cyp2c55 is regulated by the microbiota and inflammation

• Published in: The FASEB journal Vol. 38; no. 20; pp. e70117 - n/a
• Main Authors: Hilman, Adrian, Sato, Tetsu, Wijatniko, Bambang Dwi, Fujimura, So, Nakamura, Katsushi, Miura, Hiroto, Iwatsuki, Ken, Inoue, Ryo, Suzuki, Takuya
• Format: Journal Article
• Language: English
• Published: United States 31.10.2024
• Subjects: Animals; bile acid; Bile Acids and Salts - metabolism; Colitis - chemically induced; Colitis - metabolism; Colitis - microbiology; Colon - metabolism; Colon - microbiology; Cyp2c55; Dextran Sulfate; Gastrointestinal Microbiome - physiology; Inflammation - metabolism; Inflammation - microbiology; intestinal inflammation; intestinal microbiota; Intestinal Mucosa - metabolism; Intestinal Mucosa - microbiology; Male; Mice; Mice, Inbred C57BL; Pregnane X Receptor - genetics; Pregnane X Receptor - metabolism; intestinal microbiota; intestinal inflammation; Cyp2c55; bile acid

Although the mutualistic relationship between the intestinal microbiota and the human host is crucial for maintaining health, the underlying mechanisms of this relationship remain unclear. In the present study, aiming to elucidate the regulatory mechanisms governing the Cyp2c55 expression, which is...