Amino acid starvation sensing dampens IL-1β production by activating riboclustering and autophagy

• Published in: PLoS biology Vol. 16; no. 4; p. e2005317
• Main Authors: Battu, Srikanth, Afroz, Sumbul, Giddaluru, Jeevan, Naz, Saima, Huang, Weishan, Khumukcham, Saratchandra Singh, Khan, Rafiq Ahmad, Bhat, Saleem Yousuf, Qureshi, Insaf Ahmed, Manavathi, Bramanandam, Khan, Aleem Ahmed, August, Avery, Hasnain, Seyed Ehtesham, Khan, Nooruddin
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 05.04.2018; Public Library of Science (PLoS)
• Subjects: Biology and Life Sciences; Medicine and Health Sciences; Research and Analysis Methods

Activation of the amino acid starvation response (AAR) increases lifespan and acute stress resistance as well as regulates inflammation. However, the underlying mechanisms remain unclear. Here, we show that activation of AAR pharmacologically by Halofuginone (HF) significantly inhibits production of...