Magnesium supplement enhances spatial-context pattern separation and prevents fear overgeneralization

• Published in: Behavioural pharmacology Vol. 24; no. 4; p. 255
• Main Authors: Abumaria, Nashat, Luo, Lin, Ahn, Matae, Liu, Guosong
• Format: Journal Article
• Language: English
• Published: England 01.08.2013
• Subjects: Analysis of Variance; Animals; Brain - drug effects; Brain - metabolism; Conditioning (Psychology) - drug effects; Discrimination (Psychology) - drug effects; Divorce; Extinction, Psychological - drug effects; Fear - drug effects; Freezing Reaction, Cataleptic - drug effects; Magnesium - metabolism; Magnesium Compounds - pharmacology; Male; Rats; Rats, Sprague-Dawley; Space Perception - drug effects; Threonine - pharmacology

Enhancement of pattern separation could be helpful in improving the quality of normal daily learning and in treating individuals with cognitive impairment and certain psychiatric disorders. Previously, we have shown that elevating brain magnesium, by a novel magnesium compound (magnesium-L-threonate...