Beneficial Effect of Calcium Treatment for Hyperkalemia Is Not Due to "Membrane Stabilization"

• Published in: Critical care medicine Vol. 52; no. 10; p. 1499
• Main Authors: Piktel, Joseph S, Wan, Xiaoping, Kouk, Shalen, Laurita, Kenneth R, Wilson, Lance D
• Format: Journal Article
• Language: English
• Published: United States 01.10.2024
• Subjects: Action Potentials - drug effects; Animals; Calcium - metabolism; Cell Membrane - drug effects; Dogs; Electrocardiography; Hyperkalemia - drug therapy; Membrane Potentials - drug effects; Myocytes, Cardiac - drug effects
• ISSN: 1530-0293
• DOI: 10.1097/CCM.0000000000006376

Hyperkalemia is a common life-threatening condition causing severe electrophysiologic derangements and arrhythmias. The beneficial effects of calcium (Ca 2+ ) treatment for hyperkalemia have been attributed to "membrane stabilization," by restoration of resting membrane potential (RMP). Ho...