Inhibition of apoptosis by calcium ionophores in IL-3-dependent bone marrow cells is dependent upon production of IL-4

• Published in: The Journal of immunology (1950) Vol. 148; no. 5; pp. 1416 - 1422
• Main Authors: Rodriguez-Tarduchy, G, Malde, P, Lopez-Rivas, A, Collins, MK
• Format: Journal Article
• Language: English
• Published: United States Am Assoc Immnol 01.03.1992
• Subjects: Animals; Bone Marrow - drug effects; Bone Marrow - metabolism; Calcimycin - pharmacology; Calcium - physiology; Cell Cycle - drug effects; Cell Survival - drug effects; DNA - metabolism; Interleukin-3 - pharmacology; Interleukin-4 - biosynthesis; Mice

Calcium ionophores inhibit apoptosis in the IL-3-dependent cell line BAF3 and maintain the cells in a viable noncycling state. In this report, an identical effect of ionophore was also demonstrated on the multipotent IL-3-dependent progenitor cell line FDCP-MIX and on the primary IL-3-dependent cell...