Age-related changes in the antidepressant-like effect of desipramine and fluoxetine in the rat forced-swim test

• Published in: Behavioural pharmacology Vol. 27; no. 1; p. 22
• Main Authors: Olivares-Nazario, Maribel, Fernández-Guasti, Alonso, Martínez-Mota, Lucía
• Format: Journal Article
• Language: English
• Published: England 01.02.2016
• Subjects: Aging - drug effects; Aging - physiology; Aging - psychology; Animals; Antidepressive Agents - pharmacology; Depressive Disorder - drug therapy; Depressive Disorder - physiopathology; Desipramine - pharmacology; Disease Models, Animal; Dose-Response Relationship, Drug; Fluoxetine - pharmacology; Male; Motor Activity - drug effects; Motor Activity - physiology; Random Allocation; Rats, Wistar; Rotarod Performance Test; Swimming - physiology; Swimming - psychology

Some reports suggest that older patients are less responsive to antidepressants than young adults, but this idea has not been fully supported. Here, we investigated the role of aging in the behavioral effects of the antidepressants, desipramine (DMI) (5, 10, and 20 mg/kg) and fluoxetine (FLX) (5, 10...