Gαᵢ₁ and Gαᵢ₃ regulate macrophage polarization by forming a complex containing CD14 and Gab1 - Li, Xianjing; Wang, Duowei; Chen, Zhen; Lu, Ermei; Wang, Zhuo; Duan, Jingjing; Tian, Wei; Wang, Yun; You, Linjun; Zou, Yulian; Cheng, Yan; Zhu, Qingyi; et al. (Proceedings of the National Academy of Sciences - PNAS, 2015)
Keywords: Adaptor Proteins, Signal Transducing; Animals; Biological Sciences; Blotting, Western; Cell Line, Tumor; Cells, Cultured; endocytosis; Endocytosis - drug effects; G-proteins; GTP-Binding Protein alpha Subunits, Gi-Go - genetics; GTP-Binding Protein alpha Subunits, Gi-Go - metabolism; Humans; inflammation; Interleukin-12 - metabolism; Interleukin-6 - metabolism; Lipopolysaccharide Receptors - genetics; Lipopolysaccharide Receptors - metabolism; Lipopolysaccharides - pharmacology; macrophages; Macrophages - drug effects; Macrophages - metabolism; Macrophages, Peritoneal - drug effects; Macrophages, Peritoneal - metabolism; Mice, 129 Strain; Mice, Knockout; Microscopy, Confocal; Mitogen-Activated Protein Kinases - metabolism; Phosphoproteins - genetics; Phosphoproteins - metabolism; plasma membrane; Protein Binding - drug effects; Protein Subunits - genetics; Protein Subunits - metabolism; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; signal transduction; Survival Analysis; Toll-like receptor 4; Toll-Like Receptor 4 - metabolism; transcription factor NF-kappa B; Tumor Necrosis Factor-alpha - metabolism; macrophage polarization; endosome; Gαi3; Gαi1; Toll-like receptor 4