Linkage and association with the NOS2A locus on chromosome 17q11 in multiple sclerosis

• Published in: Annals of neurology Vol. 55; no. 6; pp. 793 - 800
• Main Authors: Barcellos, Lisa F., Begovich, Ann B., Reynolds, Rebecca L., Caillier, Stacy J., Brassat, David, Schmidt, Silke, Grams, Sarah E., Walker, Karen, Steiner, Lori L., Cree, Bruce A. C., Stillman, Althea, Lincoln, Robin R., Pericak-Vance, Margaret A., Haines, Jonathan L., Erlich, Henry A., Hauser, Stephen L., Oksenberg, Jorge R.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.06.2004; Willey-Liss
• Subjects: Adult; African Americans; Biological and medical sciences; Case-Control Studies; Chromosomes, Human, Pair 17; Exons - genetics; Family Health; Female; Gene Frequency; Genetic Predisposition to Disease; Genetic Variation; Haplotypes; HLA-DR2 Antigen; Humans; Linkage Disequilibrium; Male; Medical sciences; Multiple Sclerosis - epidemiology; Multiple Sclerosis - genetics; Neurology; Nitric Oxide Synthase - genetics; Polymorphism, Single Nucleotide; Multiple sclerosis; Nervous system diseases; Central nervous system disease; Genetic linkage; Genetics; Chromosome; Locus; Inflammatory disease

A large body of research supports a multifactorial cause in multiple sclerosis (MS), with an underlying genetic susceptibility likely acting in concert with undefined environmental exposures. Here, we used a highly efficient multilocus genotyping assay to study single nucleotide polymorphisms repres...