SUMO protease SENP6 protects the nucleus from hyperSUMOylation-induced laminopathy-like alterations

• Published in: Cell reports (Cambridge) Vol. 42; no. 8; p. 112960
• Main Authors: Liczmanska, Magda, Tatham, Michael H., Mojsa, Barbara, Eugui-Anta, Ania, Rojas-Fernandez, Alejandro, Ibrahim, Adel F.M., Hay, Ronald T.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 29.08.2023; Elsevier
• Subjects: CP: Cell biology; CP: Molecular biology; lamin; laminopathy; nuclear blebbing; PISM; proteomics; SENP6; SUMO; SENP6; nuclear blebbing; lamin; SUMO; proteomics; CP: Cell biology; PISM; CP: Molecular biology; laminopathy

The small ubiquitin-like modifier (SUMO) protease SENP6 disassembles SUMO chains from cellular substrate proteins. We use a proteomic method to identify putative SENP6 substrates based on increased apparent molecular weight after SENP6 depletion. Proteins of the lamin family of intermediate filament...