Fibrinogen and Vascular Smooth Muscle Cell Grafts Promote Healing of Experimental Aneurysms Treated by Embolization

• Published in: Stroke (1970) Vol. 30; no. 8; pp. 1657 - 1664
• Main Authors: Raymond, Jean, Desfaits, Anne Cécile, Roy, Daniel
• Format: Journal Article
• Language: English
• Published: United States American Heart Association, Inc 01.08.1999
• Subjects: Adenoviridae - genetics; Adenoviridae - metabolism; Aneurysm - diagnostic imaging; Aneurysm - pathology; Aneurysm - therapy; Angiography; Animals; Carotid Artery Diseases - diagnostic imaging; Carotid Artery Diseases - pathology; Carotid Artery Diseases - therapy; Cells, Cultured - metabolism; Cells, Cultured - transplantation; Cells, Cultured - virology; Disease Models, Animal; Dogs; Embolization, Therapeutic - methods; Femoral Artery - cytology; Fibrinogen - therapeutic use; Follow-Up Studies; Gene Expression; Gene Transfer Techniques; Green Fluorescent Proteins; Indicators and Reagents - metabolism; Luminescent Proteins - biosynthesis; Luminescent Proteins - genetics; Microscopy, Fluorescence; Muscle, Smooth, Vascular - metabolism; Muscle, Smooth, Vascular - transplantation; Muscle, Smooth, Vascular - virology; Tunica Intima - pathology; Wound Healing

Background and Purpose —Residual necks and recurrences frequently occur after endovascular treatment of cerebral aneurysms. Addition of fibrinogen and vascular smooth muscle cells (VSMCs) to the embolic material may promote healing of embolized aneurysms by increasing neointima formation at the neck...