Improved Fermentation Yield of Doramectin from Streptomyces avermitilis N72 by Strain Selection and Glucose Supplementation Strategies

• Published in: Fermentation (Basel) Vol. 9; no. 2; p. 121
• Main Authors: Pan, Xiaojun, Cai, Jun
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.02.2023
• Subjects: Antiparasitic agents; CHC; Cyclohexanecarboxylic acid; doramectin; Fermentation; fermentation characteristics; Fermenters; Flour; Glucose; Industrial strains; Mutagenesis; mutagenic breeding; Parasites; Parasitic diseases; Solid state fermentation; Streptomyces; Streptomyces avermitilis; Supplements; United States > US; China

Doramectin is a macrolide antiparasitic that is widely used in the treatment of mammalian parasitic diseases. Doramectin is usually produced by Streptomyces avermitilis fermentation using cyclohexanecarboxylic acid (CHC) as a precursor; however, the growth of S. avermitilis is usually inhibited by C...