In vivo activation of the hypoxia-targeted cytotoxin AQ4N in human tumor xenografts - Williams, Kaye J.; Albertella, Mark R.; Fitzpatrick, Brian; Loadman, Paul M.; Shnyder, Steven D.; Chinje, Edwin C.; Telfer, Brian A.; Dunk, Chris R.; Harris, Peter A.; Stratford, Ian J. (Molecular cancer therapeutics, 2009)
Keywords: Animals; Anthraquinones - metabolism; Anthraquinones - pharmacology; Antineoplastic Agents - pharmacology; AQ4N radio/chemotherapy; Cell Line, Tumor; Chromatography, High Pressure Liquid; Cisplatin - pharmacology; Combined Modality Therapy; Cytotoxins - metabolism; Cytotoxins - pharmacology; Drug Synergism; experimental tumors; Female; Humans; Hypoxia; Mass Spectrometry; Mice; Mice, Nude; Microscopy, Confocal; Neoplasms - metabolism; Neoplasms - pathology; Neoplasms - therapy; preclinical; prodrug; Prodrugs - metabolism; Prodrugs - pharmacology; Radiotherapy - methods; Treatment Outcome; Xenograft Model Antitumor Assays