Comparison of bulk and microfluidic methods to monitor the phase behaviour of nanoparticles during digestion of lipid-based drug formulations using in situ X-ray scattering

• Published in: Soft matter Vol. 15; no. 46; pp. 9565 - 9578
• Main Authors: Hong, Linda, Sesen, Muhsincan, Hawley, Adrian, Neild, Adrian, Spicer, Patrick T., Boyd, Ben J.
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 27.11.2019
• Subjects: Digestion; Drug Compounding - methods; Formulations; Lipase - metabolism; Lipids; Lipids - chemistry; Liposomes - chemistry; Microfluidic devices; Microfluidics; Microfluidics - instrumentation; Microfluidics - methods; Monitoring methods; Nanoparticles; Nanoparticles - chemistry; Oral administration; pH effects; Scattering, Small Angle; Small angle X ray scattering; Stability; X-Ray Diffraction - instrumentation; X-Ray Diffraction - methods; X-ray scattering

The performance of orally administered lipid-based drug formulations is crucially dependent on digestion, and understanding the colloidal structures formed during digestion is necessary for rational formulation design. Previous studies using the established bulk pH-stat approach (Hong et al. 2015),...