Pathogenesis of liver fibrosis

• Published in: Annual review of pathology Vol. 6; p. 425
• Main Authors: Hernandez-Gea, Virginia, Friedman, Scott L
• Format: Journal Article
• Language: English
• Published: United States 28.02.2011
• Subjects: Humans; Liver - immunology; Liver - pathology; Liver Cirrhosis - etiology; Liver Cirrhosis - immunology; Liver Cirrhosis - pathology; Signal Transduction - immunology

Liver fibrosis is a major cause of morbidity and mortality worldwide due to chronic viral hepatitis and, more recently, from fatty liver disease associated with obesity. Hepatic stellate cell activation represents a critical event in fibrosis because these cells become the primary source of extracel...