Laterality defects are influenced by timing of treatments and animal model

• Published in: Differentiation (London) Vol. 83; no. 1; pp. 26 - 37
• Main Author: Vandenberg, Laura N.
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.01.2012
• Subjects: Animal model; animal models; chicks; Cilia; fish; frogs; gene expression; Ion flux; Left−right asymmetry; Meta-analysis; mice; penetrance; phenotype; Regression analysis; Ion flux; Animal model; Left−right asymmetry; Regression analysis; Cilia; Meta-analysis

The timing of when the embryonic left−right (LR) axis is first established and the mechanisms driving this process are subjects of strong debate. While groups have focused on the role of cilia in establishing the LR axis during gastrula and neurula stages, many animals appear to orient the LR axis p...