Gestational Diabetes Mellitus Is Associated With Changes in the Concentration and Bioactivity of Placenta-Derived Exosomes in Maternal Circulation Across Gestation

• Published in: Diabetes (New York, N.Y.) Vol. 65; no. 3; pp. 598 - 609
• Main Authors: Salomon, Carlos, Scholz-Romero, Katherin, Sarker, Suchismita, Sweeney, Emma, Kobayashi, Miharu, Correa, Paula, Longo, Sherri, Duncombe, Gregory, Mitchell, Murray D, Rice, Gregory E, Illanes, Sebastian E
• Format: Journal Article
• Language: English
• Published: United States American Diabetes Association 01.03.2016
• Subjects: Adolescent; Adult; Case-Control Studies; Cytokines; Cytokines - metabolism; Diabetes; Diabetes, Gestational - metabolism; Enzyme-Linked Immunosorbent Assay; Exosomes - metabolism; Female; Gestational Age; Glucose Tolerance Test; Granulocyte-Macrophage Colony-Stimulating Factor - metabolism; Human Umbilical Vein Endothelial Cells - metabolism; Humans; Infant, Newborn; Inflammation; Interferon-gamma - metabolism; Interleukin-10 - metabolism; Interleukin-2 - metabolism; Interleukin-4 - metabolism; Interleukin-6 - metabolism; Interleukin-8 - metabolism; Male; Placenta - metabolism; Plasma; Pregnancy; Pregnancy Trimester, Second; Pregnancy Trimester, Third; Pulsatile Flow; ROC Curve; Tumor Necrosis Factor-alpha - metabolism; Ultrasonography, Doppler; Uterine Artery - diagnostic imaging; Young Adult

Although there is significant interest in elucidating the role of placenta-derived exosomes (PdEs) during pregnancy, the exosomal profile in pregnancies complicated by gestational diabetes mellitus (GDM) remains to be established. The aim of this study was to compare the gestational-age profile of P...