Cloning of bovine GAP and its interaction with oncogenic ras p21

• Published in: Nature (London) Vol. 335; no. 6185; p. 90
• Main Authors: Vogel, U S, Dixon, R A, Schaber, M D, Diehl, R E, Marshall, M S, Scolnick, E M, Sigal, I S, Gibbs, J B
• Format: Journal Article
• Language: English
• Published: England 01.09.1988
• Subjects: Amino Acid Sequence; Animals; Base Sequence; Brain - metabolism; Cattle; Cloning, Molecular; DNA; GTP Phosphohydrolases - metabolism; GTPase-Activating Proteins; Molecular Sequence Data; Molecular Weight; Phosphoric Monoester Hydrolases - metabolism; Proteins; Proto-Oncogene Proteins; ras GTPase-Activating Proteins

The plasma membrane-bound mammalian ras proteins of relative molecular mass 21,000 (ras p21) share biochemical and structural properties with other guanine nucleotide-binding regulatory proteins (G-proteins). Oncogenic ras p21 variants result from amino acid substitutions at specific positions that...