Increasing Effects of Selective 5-Hydroxytryptamine Type 2C Receptor Stimulation on Evoked Momentary Urethral Closure in Female Rats and Humans

• Published in: The Journal of pharmacology and experimental therapeutics Vol. 378; no. 2; pp. 60 - 68
• Main Authors: Kamo, Izumi, Nagata, Hiroshi, O’Connell, Gale, Kato, Takuya, Imanishi, Akio, Kuno, Masako, Okanishi, Satoshi, Yoshikawa, Kyoko, Nishiyama, Yuya
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2021
• Subjects: Adult; Animals; Dose-Response Relationship, Drug; Electric Stimulation; Female; Humans; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2C - drug effects; Serotonin 5-HT2 Receptor Agonists - pharmacology; Spinal Cord Injuries - physiopathology; Urethra - drug effects; Urethra - innervation; Urethra - physiology; Pves; S-LPP; MT; 5-HT2B; 5-HT2C; TMS; 5-HT; LPP; 5-HT2A

Under healthy conditions, more than one urethra-closing reflex, including both bladder afferent–independent and –dependent actions, function during momentary elevation of intravesical (bladder) pressure to prevent urinary incontinence. In the current study, the effects of a novel selective 5-hydroxy...